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本文引用的文献

1
The Kidney Biopsy in Lupus Nephritis: Past, Present, and Future.狼疮性肾炎中的肾活检：过去、现在与未来
Semin Nephrol. 2015 Sep;35(5):465-77. doi: 10.1016/j.semnephrol.2015.08.008.
2
The value of repeat kidney biopsy in quiescent Argentinian lupus nephritis patients.重复肾活检在阿根廷静止期狼疮性肾炎患者中的价值。
Lupus. 2014 Jul;23(8):840-7. doi: 10.1177/0961203313518625. Epub 2014 Jan 8.
3
The interpretation of repeat renal biopsies in patients with lupus nephritis.狼疮性肾炎患者重复肾活检的解读
Rheumatology (Oxford). 2014 Jun;53(6):1151-2. doi: 10.1093/rheumatology/ket420. Epub 2013 Dec 20.
4
The clinical significance of serial kidney biopsies in lupus nephritis.狼疮性肾炎中系列肾脏活检的临床意义。
Mod Rheumatol. 2014 May;24(3):453-6. doi: 10.3109/14397595.2013.844293. Epub 2013 Oct 18.
5
The systemic lupus international collaborating clinics (SLICC) damage index: a systematic literature review.系统性红斑狼疮国际合作临床（SLICC）损害指数：系统文献回顾。
Semin Arthritis Rheum. 2013 Dec;43(3):352-61. doi: 10.1016/j.semarthrit.2013.05.003. Epub 2013 Jun 17.
6
Changes in pathological pattern and treatment regimens based on repeat renal biopsy in lupus nephritis.狼疮性肾炎重复肾活检后病理类型和治疗方案的变化。
Chin Med J (Engl). 2012 Aug;125(16):2890-4.
7
Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis.欧洲抗风湿病联盟和欧洲肾脏协会-欧洲透析和移植协会（EULAR/ERA-EDTA）成人和儿童狼疮肾炎管理建议。
Ann Rheum Dis. 2012 Nov;71(11):1771-82. doi: 10.1136/annrheumdis-2012-201940. Epub 2012 Jul 31.
8
Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis.荷兰增殖性狼疮性肾炎诊断与治疗指南。
Neth J Med. 2012 May;70(4):199-207.
9
American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis.美国风湿病学会狼疮性肾炎筛查、治疗及管理指南。
Arthritis Care Res (Hoboken). 2012 Jun;64(6):797-808. doi: 10.1002/acr.21664.
10
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus.系统性红斑狼疮国际协作临床分类标准的推导与验证
Arthritis Rheum. 2012 Aug;64(8):2677-86. doi: 10.1002/art.34473.

在狼疮性肾炎中我们仍然需要进行肾活检吗？

Do we still need renal biopsy in lupus nephritis?

作者信息

Haładyj Ewa, Cervera Ricard

机构信息

Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain.

出版信息

Reumatologia. 2016;54(2):61-6. doi: 10.5114/reum.2016.60214. Epub 2016 Jun 3.

DOI:10.5114/reum.2016.60214
PMID:27407281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4918045/
Abstract

The natural course of systemic lupus erythematosus (SLE) is characterized by periods of disease activity and remissions. Prolonged disease activity results in cumulative organ damage. Lupus nephritis is one of the most common and devastating manifestations of SLE. In the era of changing therapy to less toxic regimens, some authors have stated that if mycophenolate mofetil can be used for the induction and maintenance treatment in all histological classes of lupus nephritis, renal biopsy can be omitted. This article aims to answer the question of what brings the bigger risk: renal biopsy or its abandonment.

摘要

系统性红斑狼疮（SLE）的自然病程特点是疾病活动期与缓解期交替出现。疾病活动期延长会导致累积性器官损害。狼疮性肾炎是SLE最常见且最具破坏性的表现之一。在治疗方案向毒性较小的方案转变的时代，一些作者指出，如果霉酚酸酯可用于所有组织学类型狼疮性肾炎的诱导和维持治疗，那么肾活检可以省略。本文旨在回答哪个带来的风险更大的问题：肾活检还是不进行肾活检。