Kochar Sps, Arora P, Chattopadhyay A B
Reader (Obstetric and Gynaecology), Armed Forces Medical College, Pune.
Director General Medical Services (Navy), Naval Headquarters, New Delhi.
Med J Armed Forces India. 2005 Oct;61(4):313-5. doi: 10.1016/S0377-1237(05)80052-8. Epub 2011 Jul 21.
Tamoxifen, used as adjuvant therapy for carcinoma breast in postmenopausal women to prevent relapse has estrogenic effect on the endometrium.
104 patients on tamoxifen for more than six months were subjected to a clinical examination and transvaginal sonography. Patients with endometrial thickness > 8 mm were further evaluated by hysteroscopy and endometrial biopsy.
35(34%) patients were symptomatic. The average endometrial thickness was 11.2 mm which correlated with duration of tamoxifen use. 27(48%) patients had abnormal hysteroscopic findings. 35 (63%) of endometrial biopsies revealed abnormal endometrium. One case of endometrial carcinoma was diagnosed. The results were statistically analysed. There is a significant association between symptomatic status and endometrial thickness and duration of tamoxifen use.
All patients on long term tamoxifen should be annually screened for endometrial pathology.
他莫昔芬作为绝经后女性乳腺癌辅助治疗药物用于预防复发时,对子宫内膜有雌激素样作用。
对104例服用他莫昔芬超过6个月的患者进行临床检查和经阴道超声检查。子宫内膜厚度>8mm的患者进一步接受宫腔镜检查和子宫内膜活检。
35例(34%)患者有症状。平均子宫内膜厚度为11.2mm,这与他莫昔芬使用时间相关。27例(48%)患者宫腔镜检查结果异常。35例(63%)子宫内膜活检显示子宫内膜异常。诊断出1例子宫内膜癌。对结果进行了统计学分析。有症状状态与子宫内膜厚度及他莫昔芬使用时间之间存在显著关联。
所有长期服用他莫昔芬的患者应每年进行子宫内膜病变筛查。