通过氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）癌症筛查计划检测前列腺癌：一项日本全国性调查的结果。
Detection of prostate cancer by an FDG-PET cancer screening program: results from a Japanese nationwide survey.
作者信息
Minamimoto Ryogo, Senda Michio, Jinnouchi Seishi, Terauchi Takashi, Inoue Tomio
机构信息
Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan; Department of Radiology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.
Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan.
出版信息
Asia Ocean J Nucl Med Biol. 2014 Spring;2(1):19-23.
OBJECTIVES
The aim of this study was to analyze detection rates and effectiveness of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) cancer screening program for prostate cancer in Japan, which is defined as a cancer-screening program for subjects without known cancer. It contains FDG-PET aimed at detection of cancer at an early stage with or without additional screening tests such as prostate-specific antigen (PSA) and magnetic resonance imaging (MRI).
METHODS
A total of 92,255 asymptomatic men underwent the FDG-PET cancer screening program. Of these, 504 cases with findings of possible prostate cancer in any screening method were analyzed.
RESULTS
Of the 504 cases, 165 were verified as having prostate cancer. Of these, only 61 cases were detected by FDG-PET, which result in 37.0% relative sensitivity and 32.8% positive predictive value (PPV). The sensitivity of PET/computed tomography (CT) scanner was higher than that of dedicated PET (44.0% vs. 20.4%). However, the sensitivity of FDG-PET was lower than that of PSA and pelvic MRI. FDG-PET did not contribute to improving the sensitivity and PPV when performed as combined screening.
CONCLUSION
PSA should be included in FDG-PET cancer screening programs to screen for prostate cancer.
目的
本研究旨在分析日本针对前列腺癌的（18）F - 氟脱氧葡萄糖正电子发射断层扫描（FDG - PET）癌症筛查项目的检出率和有效性，该项目定义为针对无已知癌症受试者的癌症筛查项目。它包括旨在早期检测癌症的FDG - PET，无论是否进行额外的筛查测试，如前列腺特异性抗原（PSA）和磁共振成像（MRI）。
方法
共有92255名无症状男性接受了FDG - PET癌症筛查项目。其中，对504例在任何筛查方法中发现可能患有前列腺癌的病例进行了分析。
结果
在这504例病例中，165例被证实患有前列腺癌。其中，仅61例通过FDG - PET检测到，相对灵敏度为37.0%，阳性预测值（PPV）为32.8%。PET/计算机断层扫描（CT）扫描仪的灵敏度高于专用PET（44.0%对20.4%）。然而，FDG - PET的灵敏度低于PSA和盆腔MRI。当作为联合筛查进行时，FDG - PET对提高灵敏度和PPV没有帮助。
结论
在FDG - PET癌症筛查项目中应纳入PSA以筛查前列腺癌。
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