[乳糜泻与血清学阴性的绒毛萎缩：CD3、CD4、CD8和CD56淋巴细胞的组织学比较及免疫组织化学研究]

[Celiac disease and negative serology villous atrophy: histological comparison and immunohistochemical study of CD3, CD4, CD8 and CD56 lymphocytes].

作者信息

Arévalo Suárez Fernando, Portugal Sabino, Barreda Carlos, Montes Pedro, Perez-Narrea María Teresa, Rodríguez Omar, Vergara Greys, Monge Eduardo

机构信息

Hospital Nacional Daniel A Carrión. Lima, Perú; Clínica Ricardo Palma. Lima, Perú; Universidad Nacional Mayor de San Marcos. Lima, Perú; Universidad Peruana de Ciencias. Lima, Perú.

Clínica Ricardo Palma. Lima, Perú; Universidad Cayetano Heredia. Lima, Perú.

出版信息

Rev Gastroenterol Peru. 2016 Apr-Jun;36(2):123-8.

PMID:27409088

Abstract

UNLABELLED

There is a group of enteropathies recently known as seronegative villous atrophy (SNVA), which can simulate celiac disease.

OBJECTIVE

The aim of this study was to describe histological and immunohistochemical differences between a group of Celiac disease and SNVA patients.

MATERIAL AND METHODS

Microscopy reexamination and Immunohistochemistry study were performed for a group of 15 celiac patients and 19 SNVA patients. Histological features as severe atrophy, crypt hyperplasia, plasma cells number, eosinophils number, neutrophils presence were studied; CD4, CD8, CD3, and CD56 markers were studied through immunohistochemistry.

RESULTS

There was a significant difference between the frequency of observation of crypt hyperplasia (p=0.0348) and plasma cells (p=0.0348) in celiac disease patients than SNVA patients. In celiac disease was bigger. The number and distribution of CD 8, CD4 and CD56 lymphocytes was similar in both groups. The percentage of CD3 positive intraepithelial lymphocytes (p=0.0144) was higher in SNVA.

CONCLUSION

Histological and immunohistochemical evaluation shows more similarities than differences. The differences found in this study suggest more humoral immune response in celiac disease than in SNVA.

摘要