Nieroda C A, Mojzisik C, Sardi A, Farrar W B, Hinkle G, Siddiqi M A, Ferrara P J, James A, Schlom J, Thurston M O
Department of Surgery, Ohio State University College of Medicine, Columbus 43210.
Surg Gynecol Obstet. 1989 Jul;169(1):35-40.
Radioimmunoguided Surgery (RIGS) uses a hand-held gamma detecting probe to identify radiolabeled monoclonal antibodies (Mab). Fourteen patients with carcinoma of the breast proved at biopsy received Mab B72.3 (5 millicuries of 125I per 1 milligram, Iodo-Gen method) intravenously six to 26 days before exploration. Probe counts were measured intraoperatively in mammary tissue and axillary lymph nodes. In the mammary tissue, the RIGS system identified tumor that was histologically confirmed in seven of eight patients and confirmed the absence in four of six patients. Probe counts were suspicious for tumor that was not proved histologically in two of 14 patients. Unsuspected tumor was identified in three of 14 patients. In axillary tissue, probe counts identified one of two tumors that were confirmed histologically and verified the absence of tumor in eight of 12 patients. Probe counts in axillary tissue were suspicious for tumor that could not be documented histologically in four of 14 patients. RIGS appears to be able to identify residual, subclinical and multicentric carcinoma of the breast and accurately delineate the pattern of antigenic drainage of tumor into adjacent lymph nodes.
放射免疫导向手术（RIGS）使用手持式γ探测仪来识别放射性标记的单克隆抗体（Mab）。14例经活检证实为乳腺癌的患者在手术探查前6至26天静脉注射Mab B72.3（每毫克含5毫居里的125I，采用碘标记法）。术中在乳腺组织和腋窝淋巴结测量探测仪计数。在乳腺组织中，RIGS系统识别出8例患者中有7例经组织学证实的肿瘤，并在6例患者中有4例证实无肿瘤。14例患者中有2例探测仪计数提示有肿瘤但未得到组织学证实。14例患者中有3例发现了未被怀疑的肿瘤。在腋窝组织中，探测仪计数识别出2例经组织学证实的肿瘤中的1例，并在12例患者中有8例证实无肿瘤。14例患者中有4例腋窝组织的探测仪计数提示有肿瘤但无法得到组织学证实。RIGS似乎能够识别乳腺的残留、亚临床和多中心癌，并准确描绘肿瘤向邻近淋巴结的抗原引流模式。
