Patwary Nurmohammed, King Sharon V, Saavedra Genaro, Preza Chrysanthe
Opt Express. 2016 Jun 13;24(12):12905-21. doi: 10.1364/OE.24.012905.
In this work, a wavefront encoded (WFE) imaging system built using a squared cubic phase mask, designed to reduce the sensitivity of the imaging system to spherical aberration, is investigated. The proposed system allows the use of a space-invariant image restoration algorithm, which uses a single PSF, to restore intensity distribution in images suffering aberration, such as sample-induced aberration in thick tissue. This provides a computational advantage over depth-variant image restoration algorithms developed previously to address this aberration. Simulated PSFs of the proposed system are shown to change up to 25% compared to the 0 µm depth PSF (quantified by the structural similarity index) over a 100 µm depth range, while the conventional system PSFs change up to 84%. Results from experimental test-sample images show that restoration error is reduced by 29% when the proposed WFE system is used instead of the conventional system over a 30 µm depth range.
在这项工作中，研究了一种使用平方立方相位掩模构建的波前编码（WFE）成像系统，该系统旨在降低成像系统对球差的敏感度。所提出的系统允许使用空间不变图像恢复算法，该算法使用单个点扩散函数（PSF）来恢复存在像差的图像中的强度分布，例如厚组织中样本引起的像差。这相对于先前开发的用于解决此像差的深度可变图像恢复算法具有计算优势。在所提出系统的模拟点扩散函数中，在100μm深度范围内，与0μm深度的点扩散函数相比（通过结构相似性指数量化）变化高达25%，而传统系统的点扩散函数变化高达84%。实验测试样本图像的结果表明，在30μm深度范围内，使用所提出的波前编码系统代替传统系统时，恢复误差降低了29%。
