Syngenta Crop Protection AG, Basel, Switzerland.
DuPont de Nemours, Mechelen, Belgium.
Risk Anal. 2017 May;37(5):930-942. doi: 10.1111/risa.12666. Epub 2016 Jul 14.
This article reviews the interactions between the REACH (Registration, Evaluation, Authorization and restriction of Chemicals) regulation and the plant protection product regulation for substances used as coformulants in the European Union, and describes generic exposure scenarios developed for their exposure and risk assessment. The REACH exposure scenarios describe the operational conditions and risk management measures used in the risk assessment of a coformulant, and as such these translate as the boundaries of safe use. The generic exposure scenarios are designed to be simple, and closely integrate with REACH use descriptors and customized exposure models. Clustering of application methods and exposure determinants resulted in four generic exposure scenarios, each covering professional workers or consumers, and application of products in liquid, granular form, or applied on seeds. When used in conjunction with appropriate exposure models, the generic exposure scenarios support efficient first-tier risk assessment of coformulants by utilizing a higher level of abstraction and conservatism than typically used in plant protection product assessments.
本文综述了欧盟中作为共溶剂使用的物质的 REACH（注册、评估、授权和限制化学品）法规与植保产品法规之间的相互作用，并描述了为共溶剂的暴露和风险评估而开发的通用暴露情景。REACH 暴露情景描述了共溶剂风险评估中使用的操作条件和风险管理措施，因此这些情景转化为安全使用的界限。通用暴露情景旨在简单，并与 REACH 使用描述符和定制暴露模型紧密结合。应用方法和暴露决定因素的聚类导致了四种通用暴露情景，每种情景都涵盖了专业工人或消费者，以及液体、颗粒形式的产品应用，或应用于种子。当与适当的暴露模型结合使用时，通用暴露情景通过利用比植保产品评估中通常使用的更高水平的抽象性和保守性，支持共溶剂的高效一级风险评估。
