Kowalski Andrzej, Pałyga Jan
Department of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University, 25-406 Kielce, Poland.
Biol Cell. 2016 Dec;108(12):339-356. doi: 10.1111/boc.201600007. Epub 2016 Aug 25.
In this review, the structural aspects of linker H1 histones are presented as a background for characterization of the factors influencing their function in animal and human chromatin. The action of H1 histone variants is largely determined by dynamic alterations of their intrinsically disordered tail domains, posttranslational modifications and allelic diversification. The interdependent effects of these factors can establish dynamic histone H1 states that may affect the organization and function of chromatin regions.
在本综述中，组蛋白H1连接体的结构方面被作为表征影响其在动物和人类染色质中功能的因素的背景呈现。组蛋白H1变体的作用很大程度上由其内在无序的尾部结构域的动态变化、翻译后修饰和等位基因多样化决定。这些因素的相互依赖效应可建立动态的组蛋白H1状态，这可能会影响染色质区域的组织和功能。
