Ovchinnikova L N, Gorkin V Z, Anokhina I P
Vopr Med Khim. 1989 Mar-Apr;35(2):124-8.
Chronic alcohol intoxication was accompanied by qualitatively new deamination reactions of cadaverine or glucosamine in dialyzed fraction of rat liver tissue homogenate. The rate of reactions was considerably more distinct in human liver and brain tissues obtained post mortem from patients with chronic alcoholism. At the same time, impairments were observed both in deamination of biogenic monoamines by membrane-bound monoamine oxidases and in ascorbate-dependent lipid peroxidation. The qualitative modifications in catalytic properties of membrane-bound monoamine oxidase, related to reactions of deamination and lipid peroxidation, appear to be of importance in chronic alcoholism and acute lethal alcohol intoxication.
慢性酒精中毒伴随着大鼠肝组织匀浆透析部分中尸胺或氨基葡萄糖新的定性脱氨反应。在慢性酒精中毒患者死后获得的人体肝脏和脑组织中，反应速率明显更高。同时，膜结合单胺氧化酶对生物源性单胺的脱氨作用以及抗坏血酸依赖性脂质过氧化作用均出现损伤。与脱氨反应和脂质过氧化反应相关的膜结合单胺氧化酶催化特性的定性改变，在慢性酒精中毒和急性致死性酒精中毒中似乎具有重要意义。
