Cartocci Veronica, Servadio Michela, Trezza Viviana, Pallottini Valentina
Department of Science, Biomedical and Biotechnology Section, University Roma Tre, Rome, Italy.
J Cell Physiol. 2017 Feb;232(2):281-286. doi: 10.1002/jcp.25488. Epub 2016 Jul 20.
Cholesterol is an important component for cell physiology. It regulates the fluidity of cell membranes and determines the physical and biochemical properties of proteins. In the central nervous system, cholesterol controls synapse formation and function and supports the saltatory conduction of action potential. In recent years, the role of cholesterol in the brain has caught the attention of several research groups since a breakdown of cholesterol metabolism has been associated with different neurodevelopmental and neurodegenerative diseases, and interestingly also with psychiatric conditions. The aim of this review is to summarize the current knowledge about the connection between cholesterol dysregulation and various neurologic and psychiatric disorders based on clinical and preclinical studies. J. Cell. Physiol. 232: 281-286, 2017. © 2016 Wiley Periodicals, Inc.
胆固醇是细胞生理学的重要组成部分。它调节细胞膜的流动性，并决定蛋白质的物理和生化特性。在中枢神经系统中，胆固醇控制突触的形成和功能，并支持动作电位的跳跃式传导。近年来，胆固醇在大脑中的作用引起了多个研究小组的关注，因为胆固醇代谢紊乱与不同的神经发育和神经退行性疾病有关，有趣的是，还与精神疾病有关。本综述的目的是基于临床和临床前研究，总结目前关于胆固醇调节异常与各种神经和精神疾病之间联系的知识。《细胞生理学杂志》2017年第232卷：281 - 286页。© 2016威利期刊公司。
