Kaledin V I, Nikolin V P, Popova N A, Budker V G, Semenova L A
Vopr Onkol. 1989;35(5):599-602.
A/HeJ mice with experimental metastases of HA-1 tumor in the liver and other organs were given therapeutic doses of cisplatin, free or encapsulated in phosphatidylcholine cholesterol freeze-thawed liposomes, intravenously. Free cisplatin treatment was found to decrease the growth rate of liver metastases by half and to extend survival by 1.5 times as compared to controls. The inhibitory effect of liposome-encapsulated cisplatin on hepatic metastases growth was more pronounced than that of the free drug although it weakly affected metastatic growth in other organs.
给患有HA-1肿瘤肝转移及其他器官转移的A/HeJ小鼠静脉注射治疗剂量的顺铂，顺铂为游离形式或包裹于磷脂酰胆碱胆固醇冻融脂质体中。结果发现，与对照组相比，游离顺铂治疗可使肝转移瘤的生长速率降低一半，并使生存期延长1.5倍。脂质体包裹的顺铂对肝转移瘤生长的抑制作用比游离药物更显著，尽管其对其他器官转移瘤生长的影响较弱。
