印度新德里淋病奈瑟菌的抗菌药物耐药性及多抗原序列分型概况
Antimicrobial Resistance and Neisseria gonorrhoeae Multiantigen Sequence Typing Profile of Neisseria gonorrhoeae in New Delhi, India.
作者信息
Mahajan Neeraj, Sood Seema, Singh Rajendra, Kapil Arti, Das Bimal Kumar, Sreenivas Vishnubhatla, Kar Hemanta Kumar, Sharma Vinod Kumar
机构信息
From the *Department of Microbiology; †Department of Biostatistics, All India Institute of Medical Sciences; ‡Department of Dermatology, STDs and Leprosy, PGIMER and Dr Ram Manohar Lohia Hospital; and §Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Sex Transm Dis. 2016 Aug;43(8):506-16. doi: 10.1097/OLQ.0000000000000471.
Molecular epidemiology of 100 consecutive gonococcal isolates collected between April 2010 and October 2013 from New Delhi was investigated using Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST) along with its association with antimicrobial resistance profiles. Neisseria gonorrhoeae isolates were assigned into 60 different sequence types and 43 (71.6%) were novel. Sole representation was seen in 76.6% sequence types. There was significant association between ST6058 and resistance to penicillin (P = 0.00) and tetracycline (P = 0.002).
对2010年4月至2013年10月期间从新德里收集的100株连续淋病奈瑟菌分离株进行了分子流行病学调查，采用淋病奈瑟菌多抗原序列分型（NG-MAST）及其与抗菌药物耐药谱的相关性分析。淋病奈瑟菌分离株被分为60种不同的序列类型，其中43种（71.6%）为新类型。76.6%的序列类型仅出现一次。ST6058与青霉素耐药（P = 0.00）和四环素耐药（P = 0.002）之间存在显著相关性。
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