Daray Federico Manuel, Rodante Demián, Carosella Laura G, Silva María Elena, Martínez Melina, Fernández Busch María V, Faccone Diego F, Rothlin Rodolfo P, Maffía Paulo C
Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires. Argentina. Paraguay 2155, piso 9, Ciudad Autónoma de Buenos Aires, Argentina.
Servicio de Emergencia, Hospital "Braulio A. Moyano", Buenos Aires, Argentina.
Pharmacopsychiatry. 2017 Jan;50(1):14-18. doi: 10.1055/s-0042-110321. Epub 2016 Jul 14.
The gene is an important candidate in pharmacogenetic studies of antipsychotic-induced weight gain (AIWG). However, inconsistent results have been obtained. The present study investigated the association between -759C>T, functional polymorphism of the receptor, and AIWG. A prospective cohort of 48 female inpatients with schizophrenia and related illness treated according to normal clinical practice with second generation antipsychotics (SGAs) risperidone, clozapine, quetiapine, and olanzapine were evaluated. Patients were weighted at admission and again at 6 weeks of hospitalization. Weight gain was defined as an increase≥7% of baseline weight. The association between polymorphisms and weight gain was evaluated. Multiple logistic regression was run to determine potential confounders. Patients with the T allele at position -759 (TT or CT) gained less weight as compared to patients who did not have the allele. This association was not affected by possible confounding factors such as age, baseline BMI, and prior psychopharmacological treatment. The T allele at position -759 protects against AIWG in female patients with schizophrenia.
该基因是抗精神病药物所致体重增加（AIWG）药物遗传学研究中的一个重要候选基因。然而，研究结果并不一致。本研究调查了受体功能多态性-759C>T与AIWG之间的关联。对48例患有精神分裂症及相关疾病的女性住院患者进行了前瞻性队列研究，这些患者按照常规临床实践接受第二代抗精神病药物（SGA）利培酮、氯氮平、喹硫平和奥氮平治疗。在患者入院时及住院6周后分别测量体重。体重增加定义为体重增加≥基线体重的7%。评估多态性与体重增加之间的关联。进行多元逻辑回归以确定潜在的混杂因素。与没有-759位点T等位基因（TT或CT）的患者相比，携带该等位基因的患者体重增加较少。这种关联不受年龄、基线BMI和既往精神药物治疗等可能混杂因素的影响。-759位点的T等位基因可预防女性精神分裂症患者出现AIWG。
