中国陕西省汉族人群 VIP 基因多态性的药物基因组学研究。
Genetic polymorphisms study of pharmacogenomic VIP variants in Han ethnic of China's Shaanxi province.
机构信息
Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
Otorhinolaryngological, Head and Neck Surgery Department, School of Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
出版信息
Environ Toxicol Pharmacol. 2016 Sep;46:27-35. doi: 10.1016/j.etap.2016.06.026. Epub 2016 Jun 27.
BACKGROUND
Multiple factors include genetic and non-genetic interactions induce to different drug response among different individuals. Lots of researches proved that different frequencies of genetic variants exists different ethnic groups. The aim of this study was to screen Han volunteers in Shaanxi for VIP gene polymorphisms.
MATERIALS AND METHODS
We genotyped 80 Very Important Pharmacogenes (VIP) (selected from the PharmGKB database) in 192 unrelated, healthy Han ethnic adults from Shaanxi, the northwest of China, and then analyzed genotyping data wtih Structure and F-statistics (Fst) analysis.
RESULTS
We compared our data with 15 other populations (Deng, Kyrgyz, Tajik, Uygur and 11 HapMap populations), and found the frequency distribution of Han population in Shaanxi is most similar with CHB. Also, Structure and Fst showed that Shaanxi Han has a closest genetic background with CHB.
CONCLUSIONS
Our study have supplemented the Han Chinese data related to pharmacogenomics and illustrated differences in genotypic frequencies of selected VIP variants' among the Han population and 15 other populations.
背景
多种因素包括遗传和非遗传相互作用导致不同个体对药物的反应不同。许多研究证实，不同的遗传变异频率存在于不同的种族群体中。本研究的目的是筛选中国西北陕西地区汉族志愿者的 VIP 基因多态性。
材料与方法
我们对来自中国西北陕西省的 192 名无亲缘关系的健康汉族成年人进行了 80 个非常重要的药物基因（VIP）（从 PharmGKB 数据库中选择）的基因分型，并使用结构和 F 统计分析（Fst）分析了基因分型数据。
结果
我们将我们的数据与其他 15 个群体（邓、吉尔吉斯斯坦、塔吉克斯坦、维吾尔族和 11 个 HapMap 群体）进行了比较，发现陕西汉族人群的频率分布与 CHB 最为相似。此外，结构和 Fst 表明，陕西汉族与 CHB 具有最接近的遗传背景。
结论
我们的研究补充了与药物基因组学相关的汉族人群数据，并说明了所选 VIP 变体的基因型频率在汉族人群和其他 15 个群体之间的差异。
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