Orlova N N, Lebedev T D, Spirin P V, Prassolov V S
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
Mol Biol (Mosk). 2016 May-Jun;50(3):395-405. doi: 10.7868/S002689841602018X.
Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acute myeloid leukemia (AML), which is widespread and difficult to treat. The review considers the mechanisms that play a significant role in AML cell malignant transformation and shows the contributions of certain genes to both remission and resistance of AML cells to various treatments.
癌症与心血管疾病一样，是医疗保健领域最重要的问题之一。造血系统疾病在30岁以下的患者中最为普遍，包括急性髓系白血病（AML），这种疾病广泛存在且难以治疗。这篇综述探讨了在AML细胞恶性转化中起重要作用的机制，并展示了某些基因对AML细胞缓解及对各种治疗的耐药性的影响。
