Pfyffer M, Schneider E, Jäger K, Küpferle L, Bollinger A
Vasa. 1989;18(2):128-35.
21 patients with acute or subacute severe ischemia at the digits due to occlusions of forearm, hand and/or finger arteries were treated by local thrombolysis with urokinase. The medicament (0.6-1.1 million units per day during 1-3 days) was applied by the intraarterial route after cannulation of the cubital or radial artery. Simultaneously, heparin (20,000 units/24 hours) was infused by the same intraarterial catheter. Complete recanalization was obtained in 5 out of 21 patients, partial recanalization with significant clinical improvement in 9 additional patients. Therapeutic success was best with mean duration of symptoms lasting less than 4 weeks and in patients with embolic occlusions. After one year half of the patients had no remaining symptoms. There were no patients with acral necrosis.
21例因前臂、手部和/或手指动脉闭塞导致手指急性或亚急性严重缺血的患者接受了尿激酶局部溶栓治疗。在经肘动脉或桡动脉插管后，通过动脉内途径应用该药物（1至3天内每天0.6 - 110万单位）。同时，通过同一动脉内导管输注肝素（20,000单位/24小时）。21例患者中有5例实现完全再通，另有9例部分再通且临床症状显著改善。症状平均持续时间少于4周的患者以及栓塞性闭塞患者的治疗效果最佳。一年后，一半的患者没有残留症状。没有患者发生肢端坏死。
