Leshchenko V M, Rukavishnikova V M, Il'chenko L S, Kukoleva L I, Shirshikova Iu I
Vestn Dermatol Venerol. 1989(3):69-72.
Three cases of chromomycosis, a disease rare in this country, are described. The authors analyze the difficulties associated with the diagnosis of this disease and review the methods of its treatment. All the patients reported in this paper have been administered polychemotherapy including intrafocal injections of amphotericin B (an antimycotic drug), iodine preparations, vitamin D2, and nizoral. This therapy has been effective in all the cases. The employed mode of administration of amphotericin B (injections round the infection focus) helps create a high concentration of the drug in the involved skin sites, resolve the nearby foci, and rules out the general reactions. Combined therapy cuts down the length of treatment.
本文描述了3例着色芽生菌病患者,该病在我国较为罕见。作者分析了该病诊断中存在的困难,并回顾了其治疗方法。本文报道的所有患者均接受了多药联合化疗,包括病灶内注射两性霉素B(一种抗真菌药物)、碘制剂、维生素D2和酮康唑。该疗法在所有病例中均有效。所采用的两性霉素B给药方式(在感染灶周围注射)有助于在受累皮肤部位形成高浓度药物,消除附近病灶,并排除全身反应。联合治疗缩短了治疗时间。