Ezeasor D N, Singh A, Sims D E
Department of Veterinary Anatomy, University of Nigeria, Nsukka.
Acta Anat (Basel). 1989;134(4):341-5. doi: 10.1159/000146712.
Caprine hemal nodes were studied by transmission electron microscopy after glutaraldehyde fixation and epoxy resin embedding. Hemal node macrophages were observed to be engaged in erythrophagocytosis. In the early stages of endocytosis, intact erythrocytes were contained in some of the heterophagic vacuoles of macrophages. Later, granular, electron-dense material appeared on erythrocytes, presumably as a result of lysosomal degradation of their matrices. Subsequently, the matrix fragmented and probably formed 'myelin-like figures' and residual bodies that dominated the macrophage cytoplasm. In addition, images of sinusoidal endothelium, reticular cells, lymphocytes and, rarely, eosinophils were observed that depicted structures resembling various stages of lysosomal digestion of erythrocyte matrix noted in macrophages. Our study provides evidence to support the fact that effete erythrocytes are filtered, besides known organs, also in caprine hemal nodes. The morphology and location of hemal nodes suggest that the organ can be an efficient blood filter.
在经戊二醛固定和环氧树脂包埋后，利用透射电子显微镜对山羊血淋巴结进行了研究。观察到血淋巴结巨噬细胞参与了红细胞吞噬作用。在内吞作用的早期阶段，巨噬细胞的一些异噬泡中含有完整的红细胞。后来，红细胞上出现了颗粒状、电子致密物质，推测这是其基质被溶酶体降解的结果。随后，基质破碎，可能形成“髓鞘样结构”和残余体，这些在巨噬细胞胞质中占主导地位。此外，还观察到了窦状内皮细胞、网状细胞、淋巴细胞以及罕见的嗜酸性粒细胞的图像，这些图像描绘了类似于巨噬细胞中红细胞基质溶酶体消化不同阶段的结构。我们的研究提供了证据支持这样一个事实，即衰老的红细胞除了在已知器官中被过滤外，在山羊血淋巴结中也会被过滤。血淋巴结的形态和位置表明该器官可能是一个有效的血液过滤器。
