Kricka Larry J, Fortina Paolo, Park Jason Y
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA.
Department of Cancer Biology, Cancer Genomics Laboratory, Sidney Kimmel Cancer Center, Thomas Jefferson University Jefferson Medical College, Philadelphia, PA, USA.
Luminescence. 2017 Mar;32(2):132-141. doi: 10.1002/bio.3170. Epub 2016 Jul 15.
Important and emerging trends at the interface of luminescence, nucleic acids and nanotechnology are: (i) the conventional luminescence labeling of nucleic acid nanostructures (e.g. DNA tetrahedron); (ii) the labeling of bulk nucleic acids (e.g. single-stranded DNA, double-stranded DNA) with nanostructured luminescent labels (e.g. copper nanoclusters); and (iii) the labeling of nucleic acid nanostructures (e.g. origami DNA) with nanostructured luminescent labels (e.g. silver nanoclusters). This review surveys recent advances in these three different approaches to the generation of nanostructured luminescently labeled nucleic acids, and includes both direct and indirect labeling methods.
发光、核酸和纳米技术交叉领域的重要且新兴的趋势包括：（i）核酸纳米结构（如DNA四面体）的传统发光标记；（ii）用纳米结构发光标记（如铜纳米簇）对大量核酸（如单链DNA、双链DNA）进行标记；以及（iii）用纳米结构发光标记（如银纳米簇）对核酸纳米结构（如折纸DNA）进行标记。本综述概述了这三种不同方法在生成纳米结构发光标记核酸方面的最新进展，包括直接和间接标记方法。
