Cha Boksik, Srinivasan R Sathish
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
BMB Rep. 2016 Aug;49(8):403-4. doi: 10.5483/bmbrep.2016.49.8.112.
The Wnt/β-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/β-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/β-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). β-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of β-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/β-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development. [BMB Reports 2016; 49(8): 403-404].
Wnt/β-连环蛋白信号通路是一条在进化上保守的信号通路，在胚胎发育和成年期体内平衡中起着关键作用。然而，关于Wnt/β-连环蛋白信号通路在淋巴管系统中的作用，我们所知有限，淋巴管系统通过吸收组织液并将其返回血液循环来调节液体平衡。在最近的这篇论文中，我们报道经典Wnt/β-连环蛋白信号通路高度活跃，且对淋巴静脉瓣（LVV）和淋巴管瓣（LV）的形成至关重要。β-连环蛋白直接与淋巴水肿相关转录因子FOXC2的调控元件结合，并以振荡剪切应力（OSS）依赖的方式激活其表达。FOXC2过表达挽救了β-连环蛋白基因敲除胚胎的表型。这些结果表明，Wnt/β-连环蛋白信号通路是一种机械转导分子，它将流体力与淋巴管发育联系起来。[《BMB报告》2016年；49(8): 403 - 404]
