Beck-Broichsitter Moritz
Institut Galien, Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.
Int J Pharm. 2016 Sep 10;511(1):262-266. doi: 10.1016/j.ijpharm.2016.07.010. Epub 2016 Jul 11.
The introduction of "Ouzo diagrams" has enhanced the applicability of the basic nanoprecipitation process for drug delivery research. The current study investigated the interaction of two relevant polymer/solvent systems, which is thought to impact the location of the stability-limit "Ouzo boundary". Viscosity measurements (Kurata-Stockmayer-Fixman approach) and static light scattering (Debye method) underlined a distinct interplay of the employed polymer (poly(lactide-co-glycolide)) with the utilized organic solvents (acetone and tetrahydrofuran). Both methods indicated that tetrahydrofuran was the "better" solvent for poly(lactide-co-glycolide). Thus, nanoprecipitation of this polymer/solvent composition resulted in larger nanoparticles. This observation can be attributed to the chain configuration of poly(lactide-co-glycolide) in the organic solvent, which influenced the extent of the break-up of the injected solvent layer. Accordingly, the stability-limit curve of the "Ouzo region" was shifted to lower poly(lactide-co-glycolide) fractions for tetrahydrofuran. Overall, the location of the "Ouzo region", which is an essential tool for drug delivery research, is influenced by the employed organic solvent. The current study described two distinct methods suitable to identify relevant polymer-solvent interactions, which dictate the stability-limit "Ouzo boundary" for relevant poly(lactide-co-glycolide).
“茴香酒图”的引入提高了基本纳米沉淀过程在药物递送研究中的适用性。本研究调查了两种相关聚合物/溶剂体系的相互作用，认为这会影响稳定性极限“茴香酒边界”的位置。粘度测量（仓田-斯托克迈耶-菲克斯曼方法）和静态光散射（德拜方法）强调了所用聚合物（聚（丙交酯-共-乙交酯））与所用有机溶剂（丙酮和四氢呋喃）之间存在明显的相互作用。两种方法均表明，四氢呋喃是聚（丙交酯-共-乙交酯）的“更佳”溶剂。因此，这种聚合物/溶剂组合物的纳米沉淀产生了更大的纳米颗粒。这一观察结果可归因于聚（丙交酯-共-乙交酯）在有机溶剂中的链构型，它影响了注入溶剂层的破裂程度。相应地，对于四氢呋喃，“茴香酒区域”的稳定性极限曲线向较低的聚（丙交酯-共-乙交酯）分数偏移。总体而言，“茴香酒区域”的位置（药物递送研究的重要工具）受所用有机溶剂的影响。本研究描述了两种适用于识别相关聚合物-溶剂相互作用的独特方法，这些相互作用决定了相关聚（丙交酯-共-乙交酯）的稳定性极限“茴香酒边界”。
