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Intravenous Tigecycline Facilitates Cure of Severe Clostridium difficile Infection (CDI) After Failure of Standard Therapy: A Case Report and Literature Review of Tigecycline Use in CDI.静脉注射替加环素有助于在标准治疗失败后治愈严重艰难梭菌感染（CDI）：1例病例报告及替加环素用于CDI的文献综述
Open Forum Infect Dis. 2016 May 12;3(2):ofw094. doi: 10.1093/ofid/ofw094. eCollection 2016 Apr.
2
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3
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Intern Med J. 2018 Jun;48(6):651-660. doi: 10.1111/imj.13742.
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Tigecycline for the treatment of severe Clostridium difficile infection.替加环素治疗严重艰难梭菌感染。
Ann Pharmacother. 2011 Jul;45(7-8):1005-10. doi: 10.1345/aph.1Q080. Epub 2011 Jul 5.
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Rev Med Chir Soc Med Nat Iasi. 2016 Jul-Sep;120(3):563-7.
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Clin Microbiol Infect. 2016 Dec;22(12):990-995. doi: 10.1016/j.cmi.2016.08.017. Epub 2016 Sep 4.
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Best strategies in recurrent or persistent Clostridium difficile infection.复发性或持续性艰难梭菌感染的最佳策略。
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Use of tigecycline for the management of Clostridium difficile colitis in oncology patients and case series of breakthrough infections.替加环素在肿瘤患者艰难梭菌结肠炎管理中的应用及突破性感染病例系列
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Impact of Tigecycline on C. difficile Outcomes: Case Series and Propensity-Matched Retrospective Study.替加环素对艰难梭菌感染结局的影响：病例系列和倾向评分匹配回顾性研究。
Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0000122. doi: 10.1128/aac.00001-22. Epub 2022 Jun 1.
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Novel Antimicrobials for the Treatment of Infection.用于治疗感染的新型抗菌药物。
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Does Adjunctive Tigecycline Improve Outcomes in Severe-Complicated, Nonoperative Infection?辅助使用替加环素能否改善严重复杂非手术感染的预后？
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本文引用的文献

1
Strategies to prevent Clostridium difficile infections in acute care hospitals: 2014 update.急性护理医院预防艰难梭菌感染的策略：2014年更新版
Infect Control Hosp Epidemiol. 2014 Sep;35 Suppl 2:S48-65. doi: 10.1017/s0899823x00193857.
2
Tigecycline suppresses toxin A and B production and sporulation in Clostridium difficile.替加环素可抑制艰难梭菌中A毒素和B毒素的产生以及芽孢形成。
J Antimicrob Chemother. 2015 Jan;70(1):153-9. doi: 10.1093/jac/dku325. Epub 2014 Aug 23.
3
Tigecycline for severe Clostridium difficile infection.替加环素用于治疗严重艰难梭菌感染。
Int J Infect Dis. 2014 Sep;26:171-2. doi: 10.1016/j.ijid.2014.04.025. Epub 2014 Jul 23.
4
Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections.艰难梭菌感染的诊断、治疗和预防指南。
Am J Gastroenterol. 2013 Apr;108(4):478-98; quiz 499. doi: 10.1038/ajg.2013.4. Epub 2013 Feb 26.
5
Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin.用替加环素、利福昔明和万古霉素成功治疗难治性艰难梭菌感染
Case Rep Med. 2012;2012:702910. doi: 10.1155/2012/702910. Epub 2012 Jul 9.
6
Treatment of first recurrence of Clostridium difficile infection: fidaxomicin versus vancomycin.艰难梭菌感染首次复发的治疗：非达霉素与万古霉素比较。
Clin Infect Dis. 2012 Aug;55 Suppl 2(Suppl 2):S154-61. doi: 10.1093/cid/cis462.
7
Recurrent refractory Clostridium difficile colitis treated successfully with rifaximin and tigecycline: a case report and review of the literature.利福昔明和替加环素成功治疗复发性难治性艰难梭菌结肠炎：一例病例报告及文献复习
Scand J Infect Dis. 2012 Mar;44(3):228-30. doi: 10.3109/00365548.2011.616224. Epub 2011 Nov 13.
8
Intravenous tigecycline in the treatment of severe recurrent Clostridium difficile colitis.静脉注射替加环素治疗严重复发性艰难梭菌结肠炎
Med J Aust. 2011 Apr 4;194(7):374-5. doi: 10.5694/j.1326-5377.2011.tb03018.x.
9
Failure of tigecycline to treat severe Clostridium difficile infection.替加环素治疗严重艰难梭菌感染失败。
Anaesth Intensive Care. 2010 Jul;38(4):755-8. doi: 10.1177/0310057X1003800339.
10
Severe and refractory Clostridium difficile infection successfully treated with tigecycline and metronidazole.用替加环素和甲硝唑成功治疗严重难治性艰难梭菌感染。
Int J Antimicrob Agents. 2010 Mar;35(3):311-2. doi: 10.1016/j.ijantimicag.2009.11.008. Epub 2009 Dec 31.

静脉注射替加环素有助于在标准治疗失败后治愈严重艰难梭菌感染（CDI）：1例病例报告及替加环素用于CDI的文献综述

Intravenous Tigecycline Facilitates Cure of Severe Clostridium difficile Infection (CDI) After Failure of Standard Therapy: A Case Report and Literature Review of Tigecycline Use in CDI.

作者信息

Navalkele Bhagyashri D, Lerner Stephen A

机构信息

Division of Infectious Diseases , Wayne State University School of Medicine, Harper University Hospital , Detroit, Michigan.

出版信息

Open Forum Infect Dis. 2016 May 12;3(2):ofw094. doi: 10.1093/ofid/ofw094. eCollection 2016 Apr.

DOI:10.1093/ofid/ofw094
PMID:27419166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4943546/
Abstract

Standard treatment for severe Clostridium difficile infection (CDI) is oral vancomycin with metronidazole. After failure of this standard regimen, treatment becomes challenging. A young woman treated for septic shock developed CDI. Standard treatment failed and she was ineligible for fecal transplant. Addition of tigecycline to her regimen resulted in cure.

摘要

严重艰难梭菌感染（CDI）的标准治疗方法是口服万古霉素加甲硝唑。在这种标准治疗方案失败后，治疗变得具有挑战性。一名因感染性休克接受治疗的年轻女性患上了CDI。标准治疗失败，且她不符合粪便移植的条件。在她的治疗方案中加用替加环素后治愈。