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个体化方向偏好管理与针对可复性盘源性疼痛的建议的效果比较:一项随机对照试验的预先计划的二次分析

Effects of individualised directional preference management versus advice for reducible discogenic pain: A pre-planned secondary analysis of a randomised controlled trial.

作者信息

Surkitt Luke D, Ford Jon J, Chan Alexander Y P, Richards Matthew C, Slater Sarah L, Pizzari Tania, Hahne Andrew J

机构信息

Low Back Research Team, College of Science, Health & Engineering, La Trobe University, Bundoora, Victoria 3085, Australia.

出版信息

Man Ther. 2016 Sep;25:69-80. doi: 10.1016/j.math.2016.06.002. Epub 2016 Jun 11.

Abstract

BACKGROUND

Low back disorders are prevalent and directional preference management is a common treatment with mixed evidence for effectiveness.

OBJECTIVES

To determine the effectiveness of individualised directional preference management plus guideline-based advice versus advice alone in participants with reducible discogenic pain of 6-week to 6-month duration.

DESIGN

Pre-planned secondary analysis of a multicentre, parallel group randomised controlled trial.

METHODS

Participants were randomly allocated to receive a 10-week physiotherapy program of 10-sessions of individualised directional preference management plus guideline-based advice (n = 40) or 2-sessions of advice alone (n = 38). Primary outcomes were back pain, leg pain and activity limitation. Outcomes were taken at baseline and 5, 10, 26, and 52-weeks.

RESULTS

Between-group differences significantly favoured directional preference management compared with advice for back pain at 5-weeks (1.28; 95% CI 0.34-2.23) and 10-weeks (1.45; 95% CI 0.51-2.40), and leg pain at 10-weeks (1.21; 95% CI 0.04-2.39). These short-term differences were not maintained. There were no significant differences between-groups for activity limitation. Secondary outcomes and responder analyses favoured directional preference management suggesting between-group differences were clinically important.

CONCLUSIONS

In people with reducible discogenic pain, individualised directional preference management plus guideline-based advice resulted in significant and rapid improvement in short-term back and leg pain compared with advice alone. These effects were not maintained at long-term and there were no differences in activity limitation. Individualised directional preference management could be considered for patients with reducible discogenic pain seeking rapid pain relief however further research is indicated.

摘要

背景

下背部疾病很常见,定向偏好管理是一种常用治疗方法,但其有效性证据不一。

目的

确定个性化定向偏好管理加基于指南的建议与单纯建议相比,对病程为6周-6个月的可缓解性椎间盘源性疼痛参与者的有效性。

设计

一项多中心、平行组随机对照试验的预先计划的二次分析。

方法

参与者被随机分配接受为期10周的物理治疗方案,其中一组接受10节个性化定向偏好管理加基于指南的建议(n = 40),另一组接受仅2节建议(n = 38)。主要结局指标为背痛、腿痛和活动受限。在基线、5周、10周、26周和52周时测量结局指标。

结果

与单纯建议相比,定向偏好管理在5周时对背痛的组间差异显著更有利(1.28;95%CI 0.34-2.23),10周时对背痛(1.45;95%CI 0.51-2.40)和10周时对腿痛(1.21;95%CI 0.04-2.39)也是如此。这些短期差异未持续存在。两组在活动受限方面无显著差异。次要结局指标和反应者分析支持定向偏好管理,表明组间差异具有临床重要性。

结论

对于可缓解性椎间盘源性疼痛患者,个性化定向偏好管理加基于指南的建议与单纯建议相比,可使短期背痛和腿痛显著且快速改善。这些效果在长期未持续存在,且在活动受限方面无差异。对于寻求快速缓解疼痛的可缓解性椎间盘源性疼痛患者,可考虑采用个性化定向偏好管理,但仍需进一步研究。

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