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Non-neoplastic Fallopian Tube Epithelium Carrying Gene Mutations of a Novel SOX2 Repressor Region is Soil of High-grade Serous Ovarian Cancer.

作者信息

Hirohashi Yoshihiko, Torigoe Toshihiko

机构信息

Department of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo 060-8556, Japan.

出版信息

EBioMedicine. 2016 Aug;10:17-8. doi: 10.1016/j.ebiom.2016.07.009. Epub 2016 Jul 10.

DOI:10.1016/j.ebiom.2016.07.009
PMID:27423191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5006660/
Abstract
摘要

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Non-neoplastic Fallopian Tube Epithelium Carrying Gene Mutations of a Novel SOX2 Repressor Region is Soil of High-grade Serous Ovarian Cancer.携带新型SOX2抑制区域基因突变的非肿瘤性输卵管上皮是高级别浆液性卵巢癌的起源。
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Int J Mol Sci. 2018 Aug 24;19(9):2512. doi: 10.3390/ijms19092512.
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The presence of mucosal iron in the fallopian tube supports the "incessant menstruation hypothesis" for ovarian carcinoma.输卵管中黏膜铁的存在支持了卵巢癌的“持续月经假说”。
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Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies.卵巢癌患者输卵管中SOX2的癌前过表达：发现与验证研究。
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Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma.将输卵管上皮细胞转化为浆液性癌的分子要求。
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引用本文的文献

1
SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery.SOX2是晚期高级别浆液性卵巢癌患者减瘤手术后有残留病灶时复发和死亡的一个有前景的预测指标。
Mol Cell Oncol. 2020 Sep 5;7(6):1805094. doi: 10.1080/23723556.2020.1805094.

本文引用的文献

1
Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies.卵巢癌患者输卵管中SOX2的癌前过表达：发现与验证研究。
EBioMedicine. 2016 Aug;10:137-49. doi: 10.1016/j.ebiom.2016.06.048. Epub 2016 Jul 2.
2
Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer.基质金属蛋白酶-10通过激活经典Wnt信号通路调节卵巢癌干细胞样细胞的干性，并且可能成为化疗耐药性卵巢癌的一个靶点。
Oncotarget. 2016 May 3;7(18):26806-22. doi: 10.18632/oncotarget.8645.
3
Lgr5 marks stem/progenitor cells in ovary and tubal epithelia.Lgr5 标记卵巢和输卵管上皮中的干细胞/祖细胞。
Nat Cell Biol. 2014 Aug;16(8):745-57. doi: 10.1038/ncb3000. Epub 2014 Jul 6.
4
SOX2 expression associates with stem cell state in human ovarian carcinoma.SOX2 表达与人卵巢癌细胞的干细胞状态相关。
Cancer Res. 2013 Sep 1;73(17):5544-55. doi: 10.1158/0008-5472.CAN-12-4177. Epub 2013 Jul 18.
5
Lgr proteins in epithelial stem cell biology.Lgr 蛋白在上皮干细胞生物学中的作用。
Development. 2013 Jun;140(12):2484-94. doi: 10.1242/dev.083113.
6
Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche.交界区卵巢表面上皮包含一个易患癌的干细胞巢。
Nature. 2013 Mar 14;495(7440):241-5. doi: 10.1038/nature11979. Epub 2013 Mar 6.
7
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.通过特定因子从小鼠胚胎和成体成纤维细胞培养物中诱导多能干细胞。
Cell. 2006 Aug 25;126(4):663-76. doi: 10.1016/j.cell.2006.07.024. Epub 2006 Aug 10.