Kalidindi Anisha, Kelly Sean D, Singleton Kaela S, Guzman Dora, Merrill Liana, Willard Stephanie L, Shively Carol A, Neigh Gretchen N
Department of Biology, Emory College, Atlanta, GA, USA.
Department of Physiology, Emory University, Atlanta, GA, USA.
Physiol Behav. 2017 Apr 1;172:12-15. doi: 10.1016/j.physbeh.2016.07.007. Epub 2016 Jul 14.
Depression is a common and debilitating mood disorder that impacts women more often than men. The mechanisms that result in depressive behaviors are not fully understood; however, the hippocampus has been noted as a key structure in the pathophysiology of depression. In addition to neural implications of depression, the cardiovascular system is impacted. Although not as commonly considered, the cerebrovasculature is critical to brain function, impacted by environmental stimuli, and is capable of altering neural function and thereby behavior. In the current study, we assessed the relationship between depressive behavior and a marker of vascularization of the hippocampus in adult female cynomolgus macaques (Macaca fascicularis). Similar to previously noted impacts on neuropil and glia, the depressed phenotype predicts a reduction in a marker of vascular length in the anterior hippocampus. These data reinforce the growing recognition of the effects of depression on vasculature and support further consideration of vascular endpoints in studies aimed at the elucidation of the mechanisms underlying depression.
抑郁症是一种常见且使人衰弱的情绪障碍，女性比男性更易受其影响。导致抑郁行为的机制尚未完全明确；然而，海马体被认为是抑郁症病理生理学中的关键结构。除了抑郁症的神经影响外，心血管系统也会受到影响。尽管通常未被如此考虑，但脑血管系统对脑功能至关重要，受环境刺激影响，且能够改变神经功能，进而影响行为。在当前研究中，我们评估了成年雌性食蟹猴（猕猴）抑郁行为与海马体血管生成标志物之间的关系。与先前对神经毡和神经胶质的影响类似，抑郁表型预示着前海马体血管长度标志物的减少。这些数据强化了人们对抑郁症对血管系统影响的日益认识，并支持在旨在阐明抑郁症潜在机制的研究中进一步考虑血管终点指标。
