Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.
作者信息
Dwyer Michael P, Keertikar Kerry M, Chen Lei, Tong Ling, Selyutin Oleg, Nair Anilkumar G, Yu Wensheng, Zhou Guowei, Lavey Brian J, Yang De-Yi, Wong Michael, Kim Seong Heon, Coburn Craig A, Rosenblum Stuart B, Zeng Qingbei, Jiang Yueheng, Shankar Bandarpalle B, Rizvi Razia, Nomeir Amin A, Liu Rong, Agrawal Sony, Xia Ellen, Kong Rong, Zhai Ying, Ingravallo Paul, Asante-Appiah Ernest, Kozlowski Joseph A
机构信息
Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
出版信息
Bioorg Med Chem Lett. 2016 Aug 15;26(16):4106-11. doi: 10.1016/j.bmcl.2016.06.063. Epub 2016 Jun 25.
A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles.
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