Analytical Section of Attached Hospital of Jining Medical College, Jining City, Shandong Province, PR China.
Radiology Department, Jining NO.1 People's Hospital, Shandong Province, PR China.
Clin Chim Acta. 2016 Sep 1;460:236-9. doi: 10.1016/j.cca.2016.07.007. Epub 2016 Jul 14.
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disease resulting from excessive activation and non-malignant proliferation of macrophages and T lymphocytes. Whether it can be caused by cholecystitis has not yet been reported in the world.
A 4-year-old girl was admitted to hospital with cholecystitis. The patient was diagnosed with hemophagocytic lymphohistiocytosis after 3days of admission based on the results of laboratory tests showing hypofibrinogenemia, hypertriglyceridemia, thrombocytopenia, anemia and leukopenia.
From this case experience, if a timely symptomatic treatment is given, the condition of the patient with secondary HLH can be alleviated. This is the first report of cholecystitis-induced hemophagocytic syndrome in the world also.
噬血细胞性淋巴组织细胞增生症（HLH）是一种罕见的、危及生命的疾病，由巨噬细胞和 T 淋巴细胞过度激活和非恶性增殖引起。世界范围内尚未有报道称胆囊炎是否会引发噬血细胞性淋巴组织细胞增生症。
一名 4 岁女孩因胆囊炎入院。该患者在入院 3 天后，根据实验室检查结果（纤维蛋白原降低、甘油三酯升高、血小板减少、贫血和白细胞减少），被诊断为噬血细胞性淋巴组织细胞增生症。
从该病例经验中可以看出，如果给予及时对症治疗，继发性 HLH 患者的病情可以得到缓解。这也是世界上首例胆囊炎引起噬血细胞综合征的报道。
