P'ianov R P
Arkh Patol. 1989;51(4):68-71.
A case of meconial disease not associated with mucoviscidosis registered in 0.08% of perinatal autopsies is described in a premature girl who died 46 hours after her birth. Productive exudative meconial peritonitis that had developed due to intestinal wall perforation caused by meconium plug pressure was detected on the section. Microscopically, there were abundant squamous epithelial scales in the fibrinous exudate and commissures, whereas in the submucosal layer of the intestinal wall there were productive aseptic meconial granulomas whose components are squamous epithelial scales in addition to cellular elements. Searches for granulomas are made concurrently with examination of great quantities of histologic sections, but their detection is valuable for differential diagnosis of newborn ulcerous enterocolitis.
本文描述了一例胎粪性疾病，该疾病与胰腺囊性纤维化无关，在围产期尸检中的发生率为0.08%。病例为一名早产女婴，出生46小时后死亡。尸检发现，因胎粪栓压迫导致肠壁穿孔，进而引发了渗出性胎粪性腹膜炎。显微镜下观察，在纤维素渗出物和粘连处有大量鳞状上皮鳞片，而在肠壁黏膜下层有增生性无菌性胎粪肉芽肿，其成分除细胞成分外，还有鳞状上皮鳞片。在检查大量组织切片的同时查找肉芽肿，但它们的发现对于新生儿溃疡性小肠结肠炎的鉴别诊断具有重要价值。
