Yu Heng-Yi, Li Juan, Liu Ye, Wu Wen-Ming, Ruan Han-Li
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China; Department of Pharmacy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Department of Pharmacy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Fitoterapia. 2016 Sep;113:64-8. doi: 10.1016/j.fitote.2016.07.005. Epub 2016 Jul 15.
Five new triterpenoids, named schiglausins P-T (1-5), together with twelve known analogues (6-17), were isolated from the fruit of Schisandra glaucescens Diels. Their structures were determined by various spectroscopic methods, including HRESIMS, 1D and 2D NMR spectra and CD experiment. Additionally, all these compounds were tested for their cytotoxicities against B16 mouse melanoma cell line. Compounds 8, 11, 14, and 15 exhibited moderate anti-proliferative effects against B16 cells with IC50 values ranging from 3.64 to 27.00μM.
从五味子（Schisandra glaucescens Diels）果实中分离得到了5个新的三萜类化合物，命名为schiglausins P - T（1 - 5），以及12个已知类似物（6 - 17）。通过各种光谱方法，包括高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振谱（1D和2D NMR）以及圆二色光谱（CD）实验确定了它们的结构。此外，还测试了所有这些化合物对B16小鼠黑色素瘤细胞系的细胞毒性。化合物8、11、14和15对B16细胞表现出中等程度的抗增殖作用，IC50值在3.64至27.00μM之间。
