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预测减重手术后的切口疝:基于2161例手术的风险分层模型

Predicting incisional hernia after bariatric surgery: a risk stratification model based upon 2161 operations.

作者信息

Basta Marten N, Mirzabeigi Michael N, Shubinets Valeriy, Kelz Rachel R, Williams Noel N, Fischer John P

机构信息

Department of Plastic & Reconstructive Surgery, Brown University, Rhode Island Hospital, Providence, Rhode Island.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.

出版信息

Surg Obes Relat Dis. 2016 Sep-Oct;12(8):1466-1473. doi: 10.1016/j.soard.2016.03.022. Epub 2016 Mar 23.

Abstract

BACKGROUND

Incisional hernia (IH) is a persistent cause of morbidity and diminished quality of life and a substantial source of healthcare resource utilization. The literature suggests prophylactic mesh augmentation reduces IH risk in bariatric surgery, but no predictive models are available.

OBJECTIVES

Identify factors associated with IH after bariatric surgery to develop a clinically actionable preoperative risk stratification tool to optimize outcomes and mitigate healthcare costs after bariatric surgery.

SETTING

University hospital, United States.

METHODS

All patients undergoing open or laparoscopic bariatric surgery from January 2005 to June 2013 at one institution were identified. Co-morbidities and operative characteristics were assessed. The primary outcome was surgically treated IH after index procedures. Patients with prior hernia,<1-year follow-up, or body mass index<40 kg/m were excluded. Cox hazard regression modeling with bootstrapped validation, risk factor stratification, and assessment of model performance were conducted.

RESULTS

A total of 2161 bariatric patients were included, 2.4% of whom developed IH (follow-up 28.3±25.4 mo). Predictors for IH included open surgical approach (hazard ratio [HR] = 10.3), malnutrition (HR = 3.10), prior abdominal surgery (HR = 2.89), and body mass index>60 kg/m (HR = 2.60). Based on these risk factors, patients were stratified into low-, moderate-, and high-risk categories for IH development. Of the high-risk patients, 15.2% developed IH compared with .6% of low-risk patients (C-statistic = .85). Treatment of IH and associated complications exceeded $3.5 million in healthcare costs.

CONCLUSION

Bariatric surgery conferred an IH risk of 2.4%. IH was associated with additional readmissions and complications and substantially greater costs and resource utilization. This risk stratification tool identifies candidates for prophylactic mesh augmentation, which may optimize outcomes while mitigating costs.

摘要

背景

切口疝(IH)是导致发病和生活质量下降的持续原因,也是医疗资源利用的重要来源。文献表明,预防性网片增强可降低减重手术中IH的风险,但尚无预测模型。

目的

确定减重手术后与IH相关的因素,以开发一种临床可行的术前风险分层工具,以优化减重手术后的结果并降低医疗成本。

地点

美国大学医院。

方法

确定2005年1月至2013年6月在一家机构接受开放或腹腔镜减重手术的所有患者。评估合并症和手术特征。主要结局是初次手术后接受手术治疗的IH。排除既往有疝、随访时间<1年或体重指数<40 kg/m²的患者。进行了带有自举验证的Cox风险回归建模、风险因素分层和模型性能评估。

结果

共纳入2161例减重患者,其中2.4%发生了IH(随访时间28.3±25.4个月)。IH的预测因素包括开放手术方式(风险比[HR]=10.3)、营养不良(HR=3.10)、既往腹部手术(HR=2.89)和体重指数>60 kg/m²(HR=2.60)。基于这些风险因素,将患者分为IH发生的低、中、高风险类别。高风险患者中,15.2%发生了IH,而低风险患者为0.6%(C统计量=0.85)。IH及其相关并发症的治疗医疗费用超过350万美元。

结论

减重手术导致IH的风险为2.4%。IH与再次入院和并发症增加以及成本和资源利用大幅增加相关。这种风险分层工具可识别预防性网片增强的候选者,这可能在降低成本的同时优化结果。

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