a Department of Psychiatry, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
b Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine , Federal University of Ceará , Fortaleza , CE , Brazil.
World J Biol Psychiatry. 2018 Apr;19(3):200-209. doi: 10.1080/15622975.2016.1213881. Epub 2016 Aug 30.
The aim of the present study is to delineate the associations between body image dissatisfaction in pregnant women and immune-inflammatory biomarkers, i.e., C-reactive protein (CRP), zinc and IgA/IgM responses to tryptophan and tryptophan catabolites (TRYCATs).
We assessed 49 pregnant and 24 non-pregnant females and assessed Body Image Satisfaction (BIS) scores at the end of term (T1), and 2-4 days (T2) and 4-6 weeks (T3) after delivery. Subjects were divided in those with a lowered BIS score (≤ 3) versus those with a higher score.
Logistic regression analysis showed that a lowered T1 BIS score was predicted by CRP levels and IgA responses to tryptophan (negative) and TRYCATs (positive), perinatal depression, body mass index (BMI) and age. The sum of quinolinic acid, kynurenine, 3-OH-kynurenine and 3-OH-anthranilic acid (reflecting brain quinolinic acid contents) was the single best predictor. In addition, a large part of the variance in the T1, T2 and T3 BIS scores was explained by IgA responses to tryptophan and TRYCATs, especially quinolinic acid.
Body image dissatisfaction is strongly associated with inflammation and mucosa-derived IDO activation independently from depression, pregnancy, BMI and age. IgA responses to peripheral TRYCATs, which determine brain quinolinic acid concentrations, also predict body image dissatisfaction.
本研究旨在描绘孕妇的身体意象不满与免疫炎症生物标志物之间的关联，即 C 反应蛋白（CRP）、锌以及色氨酸和色氨酸分解产物（TRYCATs）的 IgA/IgM 反应。
我们评估了 49 名孕妇和 24 名非孕妇，并在妊娠末期（T1）、分娩后 2-4 天（T2）和 4-6 周（T3）评估了身体意象满意度（BIS）评分。将受试者分为 BIS 评分较低（≤3）和较高的两组。
逻辑回归分析显示，T1 时 BIS 评分降低与 CRP 水平和色氨酸的 IgA 反应（阴性）和 TRYCATs（阳性）、围产期抑郁、体重指数（BMI）和年龄有关。喹啉酸、犬尿氨酸、3-OH-犬尿氨酸和 3-OH-邻氨基苯甲酸（反映脑内喹啉酸含量）的总和是唯一的最佳预测指标。此外，T1、T2 和 T3 的 BIS 评分的大部分变异可以用色氨酸和 TRYCATs 的 IgA 反应来解释，尤其是喹啉酸。
身体意象不满与炎症和黏膜衍生的 IDO 激活密切相关，与抑郁、妊娠、BMI 和年龄无关。外周 TRYCATs 的 IgA 反应决定了脑内喹啉酸的浓度，也可以预测身体意象不满。
