Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Metab Brain Dis. 2017 Oct;32(5):1571-1583. doi: 10.1007/s11011-017-0040-2. Epub 2017 Jun 9.
Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with (n = 24) and without prenatal depression (n = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not NO-adducts, were significantly reduced at the end of term. There were no significant associations between IgM responses to OSEs and perinatal depression, whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly associated with a lifetime major depression. IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated. The attenuation of natural IgM-mediated responses to OSEs at the end of term may indicate lowered activity of this part of the compensatory (anti-)inflammatory reflex system and may be partly explained by lowered bacterial translocation. Increased IgM responses to NO-cysteinyl is a biomarker of lifetime depression and may be induced by bacterial translocation. Natural IgM-mediated autoimmune responses, increased nitrosylation and higher CRP levels may have negative regulatory effects on the TRYCAT pathway.
免疫球蛋白（Ig）M 对氧化特异性表位（OSEs）和一氧化氮（NO）加合物的反应与重度抑郁症和生理躯体症状显著相关。在孕妇中（n=24）和没有产前抑郁症的孕妇中（n=25）以及 24 名非孕妇中检测了妊娠期末期血清 IgM 对 OSEs 和 NO 加合物的反应。分析了对革兰氏阴性肠道共生菌（漏肠指数）的 IgM/IgA 反应和对色氨酸分解产物（TRYCATs）的 IgA/IgM 反应的 IgM/IgA 反应。在妊娠期末期，OSEs 的 IgM 反应显著降低，但 NO 加合物的 IgM 反应没有显著降低。OSEs 的 IgM 反应与围产期抑郁症之间没有显著相关性，而 NO 加合物的 IgM 反应，特别是 NO-半胱氨酸，与终生重度抑郁症显著相关。OSEs 和 NO-半胱氨酸的 IgM 反应与革兰氏阴性菌，特别是摩根摩根菌、肺炎克雷伯菌和柠檬酸杆菌的 IgA/IgM 反应显著相关。NO 加合物和 OSEs 的 IgM 反应，特别是丙二醛和肉豆蔻酸，与 C 反应蛋白（CRP）呈负相关，而 TRYCAT 途径的活性与终生抑郁和铜绿假单胞菌呈正相关。妊娠期末期 OSEs 自然 IgM 介导的反应减弱可能表明该部分补偿（抗炎）反射系统的活性降低，部分原因可能是细菌易位降低。NO-半胱氨酸的 IgM 反应增加是终生抑郁症的生物标志物，可能是由细菌易位引起的。天然 IgM 介导的自身免疫反应、增加的亚硝化和更高的 CRP 水平可能对 TRYCAT 途径具有负调节作用。
