三个治疗周期内重复使用A型肉毒杆菌毒素治疗静止期眉间纹。
Repeated OnabotulinumtoxinA Treatment of Glabellar Lines at Rest Over Three Treatment Cycles.
作者信息
Carruthers Alastair, Carruthers Jean, Fagien Steven, Lei Xiaofang, Kolodziejczyk Julia, Brin Mitchell F
机构信息
Departments of *Dermatology and Skin Science, and †Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada; ‡Private Practice, Boca Raton, Florida; §Department of Clinical Development, Allergan plc, Irvine, California; ¶Department of Neurology, University of California, Irvine, California.
出版信息
Dermatol Surg. 2016 Sep;42(9):1094-101. doi: 10.1097/DSS.0000000000000704.
BACKGROUND
OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at rest; however, less is known regarding the effect of repeat treatment on more severe lines at rest.
OBJECTIVE
To assess the effect of repeated onabotulinumtoxinA treatment for reduction of glabellar lines at rest.
METHODS
Subjects 18 to 75 years old with at least mild glabellar lines at rest, as assessed by the validated Facial Wrinkle Scale (FWS) with photonumeric guide (score ≥ 1), received 3 treatments of 20 U onabotulinumtoxinA 4 months apart (N = 225). "Response" was defined as elimination of glabellar lines at rest (FWS score = 0) at any time point (Days 7, 30, 60, 90, and 120). Effect of treatment cycle on response was analyzed using repeated measures logistic regressions (p < .05).
RESULTS
Most subjects were female (85%) and white (88%) (age range: 35-54 years). The likelihood of significant response was as follows: for all subjects combined (odds ratio [OR]: 1.31), for subjects with mild resting lines at baseline (OR: 1.49), and for older women (≥55 years) with mild resting lines at baseline (OR: 2.22). Of all subjects, 76% responded after 1 treatment, and 45% responded in all 3 cycles.
CONCLUSION
Subjects repeatedly treated with onabotulinumtoxinA showed progressive improvement in glabellar lines at rest.
背景
A型肉毒毒素已被证明有能力消除静息状态下的轻度眉间纹；然而，关于重复治疗对静息状态下更严重皱纹的效果，人们了解较少。
目的
评估重复注射A型肉毒毒素治疗对减少静息状态下眉间纹的效果。
方法
年龄在18至75岁之间、经有效验证的面部皱纹量表（FWS）及光数字指南评估静息状态下至少有轻度眉间纹（评分≥1）的受试者，接受3次20单位A型肉毒毒素治疗，每次治疗间隔4个月（N = 225）。“反应”定义为在任何时间点（第7、30、60、90和120天）静息状态下眉间纹消失（FWS评分 = 0）。使用重复测量逻辑回归分析治疗周期对反应的影响（p < 0.05）。
结果
大多数受试者为女性（85%）和白人（88%）（年龄范围：35 - 54岁）。显著反应的可能性如下：所有受试者综合起来（优势比[OR]：1.31），基线时有轻度静息皱纹的受试者（OR：1.49），以及基线时有轻度静息皱纹的老年女性（≥55岁）（OR：2.22）。在所有受试者中，76%在1次治疗后有反应，45%在所有3个周期中均有反应。
结论
重复接受A型肉毒毒素治疗的受试者静息状态下的眉间纹有逐步改善。
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