Department of Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
University of California-Irvine, Irvine, CA, USA.
Handb Exp Pharmacol. 2021;263:161-170. doi: 10.1007/164_2019_347.
When one considers the avalanche of new indications and uses for botulinum toxins, it is truly surprising that this has all happened in such a short time. And the safety and dependability of these products are profound, when used appropriately. There is still much to be discovered about the potential of this agent when you contemplate the profound non-cosmetic benefits reported by clinicians and scientists from around the world. The mechanism of action has been studied in depth, and yet the benefits appreciated by people with chronic migraine or major depressive disorder, for instance, are unlikely to be explained by our current mechanistic understanding. Given that these toxins control acetylcholine at the motor end plates, and given that acetylcholine is central to practically every cell in the body, it will not be surprising to find that botulinum toxin researchers will be enjoying many decades of fruitful studies. The advent of the non-surgical aesthetic physician has helped push the clinical utilization of botulinum toxins well beyond its original adoption by oculoplastic surgeons in their patients with blepharospasm. We can expect that the next edition of this book to have a dozen or more new indications which will surprise us all.
当人们考虑到肉毒毒素新的适应证和用途如雪崩般涌现时，令人惊讶的是，这一切在如此短的时间内发生了。而且，当这些产品被适当地使用时，其安全性和可靠性是深远的。当你考虑到来自世界各地的临床医生和科学家报告的深刻的非美容益处时，这种药物的潜在作用还有很多需要发现。其作用机制已经被深入研究，但对于患有慢性偏头痛或重度抑郁症的人来说，他们所体会到的益处，可能无法用我们目前的机械理解来解释。鉴于这些毒素在运动终板处控制乙酰胆碱，并且鉴于乙酰胆碱是体内几乎每个细胞的核心物质，因此，肉毒毒素研究人员将享受数十年富有成效的研究也就不足为奇了。非手术美容医师的出现，帮助推动了肉毒毒素的临床应用，远远超出了眼整形外科医生在眼睑痉挛患者中的最初应用。我们可以预期，这本书的下一版将有十几个或更多的新适应证，这将让我们所有人感到惊讶。
