Edwards Meghan K, Loprinzi Paul D
Physical Activity Epidemiology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, MS 38677, United States.
Jackson Heart Study Vanguard Center of Oxford, Physical Activity Epidemiology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, MS 38677, United States.
Int J Cardiol. 2016 Oct 15;221:755-8. doi: 10.1016/j.ijcard.2016.07.137. Epub 2016 Jul 9.
Emerging work identifies red blood cell distribution width (RDW) as a unique biomarker independently associated with cardiovascular disease and mortality. Encouragingly, recent research demonstrates individual associations of sedentary behavior, physical activity and cardiorespiratory fitness with RDW. However, no study has evaluated their independent and combined associations on RDW, which was this study's purpose.
Data from the 2003-2004 National Health and Nutrition Examination Survey were used (N=627 adults 20-49yrs). Sedentary behavior and MVPA were objectively assessed (accelerometry) with cardiorespiratory fitness determined from a submaximal treadmill-based test. Participants were classified as above or below the median values for each of these three parameters, with a PACS (Physical Activity Cardiorespiratory Sedentary) score ranging from 0 to 3, indicating the participant number of these three positive characteristics. A blood sample was obtained from each participant to assess RDW.
Only above median MVPA (OR=0.47; 95% CI: 0.32-0.68) was independently associated with a reduced odds of having an elevated RDW. With regard to the additive model, and after adjustment, the odds ratio (95% CI) for the PACS score of 1 (vs. 0), 2 (vs. 0), and 3 (vs. 0), respectively, were 0.81 (0.45-1.45; P=0.46), 0.66 (0.44-0.99; P=0.04) and 0.35 (0.18-0.68; P=0.004).
When considering sedentary behavior, MVPA, and cardiorespiratory fitness, only MVPA was associated with reduced odds of elevated RDW, but those with all three characteristics had the lowest odds of elevated RDW.
新出现的研究将红细胞分布宽度（RDW）确定为一种与心血管疾病和死亡率独立相关的独特生物标志物。令人鼓舞的是，最近的研究表明久坐行为、身体活动和心肺适能与RDW之间存在个体关联。然而，尚无研究评估它们对RDW的独立和综合关联，而这正是本研究的目的。
使用了2003 - 2004年国家健康与营养检查调查的数据（N = 627名20 - 49岁的成年人）。通过加速度计客观评估久坐行为和中度至剧烈身体活动（MVPA），并通过基于亚极量跑步机测试确定心肺适能。参与者被分为这三个参数各自中位数以上或以下，身体活动心肺久坐（PACS）评分范围为0至3，表示具有这三个积极特征的参与者数量。从每个参与者采集血样以评估RDW。
只有高于中位数的MVPA（比值比[OR]=0.47；95%置信区间[CI]：0.32 - 0.68）与RDW升高几率降低独立相关。关于相加模型，调整后，PACS评分为1（对比0）、2（对比0）和3（对比0）的比值比（95% CI）分别为0.81（0.45 - 1.45；P = 0.46）、0.66（0.44 - 0.99；P = 0.04）和0.35（0.18 - 0.68；P = 0.004）。
在考虑久坐行为、MVPA和心肺适能时，只有MVPA与RDW升高几率降低相关，但具有所有这三个特征的人RDW升高几率最低。
