Wang Zhi-Feng, Chen Hong-Lin
Department of Neurosurgery, Nantong First People's Hospital, North Haierxiang Road 6#, Nantong City, Jiangsu Province, 226001, PR China.
Nantong University, Qixiu Road 19#, Nantong City, Jiangsu Province, PR China.
Clin Neurol Neurosurg. 2016 Sep;148:79-84. doi: 10.1016/j.clineuro.2016.07.003. Epub 2016 Jul 4.
The aim of this analysis was to perform a meta-analysis assessing the relationship between isocitrate dehydrogenase 1 (IDH1) mutation and preoperative seizure in low-grade gliomas.
Systematic computerised searches of the PubMed and Web of Knowledge were performed. The meta-analysis of pooled odds ratio (OR) and 95% confidence interval (CI) for preoperative seizure risk stratified by IDH1 mutation status were calculated.
Five studies with 540 patients were included for meta-analysis. The preoperative seizure incidence ranged from 73.54% to 94.12% in the IDH1 Mutation (+) group, compared 37.50%-76.92% in the IDH1 Mutation (-) group. The pooled crude OR was 2.750 (95% CI 1.763-4.290; Z=4.46, P=0.000). The Begg's test (z=0.73, P=0.462), the Egger's test (t=0.41, P=0.708) and symmetrical funnel plot suggested no significant publication bias. Sensitivity analysis by only pooled adjusted ORs showed the pooled OR was 2.740 (95% CI 1.593-4.714; Z=3.64, P=0.000) which indicated the results were robust. Meta-regression analysis showed preoperative seizure OR was not related with preoperative seizure incidence (t=0.37, P=0.736), and not related with IDH1 mutation rate (t=1.85, P=0.162).
Our meta-analysis indicated that IDH1 mutation was related with preoperative seizure in low-grade gliomas.
本分析旨在进行一项荟萃分析，评估异柠檬酸脱氢酶1（IDH1）突变与低级别胶质瘤术前癫痫发作之间的关系。
对PubMed和Web of Knowledge进行系统的计算机检索。计算按IDH1突变状态分层的术前癫痫发作风险的合并比值比（OR）和95%置信区间（CI）的荟萃分析。
纳入五项研究，共540例患者进行荟萃分析。IDH1突变（+）组术前癫痫发作发生率为73.54%至94.12%，而IDH1突变（-）组为37.50%至76.92%。合并粗OR为2.750（95%CI 1.763 - 4.290；Z = 4.46，P = 0.000）。Begg检验（z = 0.73，P = 0.462）、Egger检验（t = 0.41，P = 0.708）和对称漏斗图表明无显著发表偏倚。仅通过合并调整后的OR进行敏感性分析显示，合并OR为2.740（95%CI 1.593 - 4.714；Z = 3.64，P = 0.000），表明结果稳健。荟萃回归分析显示，术前癫痫发作OR与术前癫痫发作发生率无关（t = 0.37，P = 0.736），与IDH1突变率无关（t = 1.85，P = 0.162）。
我们的荟萃分析表明，IDH1突变与低级别胶质瘤术前癫痫发作有关。
