Hagve T A, Narce M, Grønn M, Christensen E, Ulmann L, Poisson J P, Christophersen B
Institute of Clinical Biochemistry, University of Oslo, Rikshospitalet, Norway.
Biochim Biophys Acta. 1989 Jul 17;1004(1):143-6. doi: 10.1016/0005-2760(89)90225-7.
When alpha-bromopalmitate was fed to rats for 9-30 days, the level of serum triacylglycerol increased up to 2-fold over the concentration of controls. alpha-Bromopalmitate treatment had no effect on concentration of complex lipids in liver, while the triacylglycerol level in heart was significantly enhanced. From metabolic studies using isolated hepatocytes and liver microsomes, it is suggested that the increased serum triacylglycerol level after alpha-bromopalmitate feeding is mainly due to reduced fatty acid oxidation in both liver and peripheral tissues, and to a lesser extent, to inhibited fatty acid uptake and esterification.
当给大鼠喂食α-溴代棕榈酸酯9至30天时，血清三酰甘油水平比对照组浓度升高了两倍。α-溴代棕榈酸酯处理对肝脏中复合脂质的浓度没有影响，而心脏中的三酰甘油水平显著升高。通过使用分离的肝细胞和肝微粒体进行的代谢研究表明，喂食α-溴代棕榈酸酯后血清三酰甘油水平升高主要是由于肝脏和外周组织中脂肪酸氧化减少，以及在较小程度上由于脂肪酸摄取和酯化受到抑制。
