Huang Jun, Wang Bin, Hui Ke, Zeng Jin, Fan Jinhai, Wang Xinyang, Hsieh Jer-Tsong, He Dalin, Wu Kaijie
Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Department of Urology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA.
Oncol Rep. 2016 Sep;36(3):1693-701. doi: 10.3892/or.2016.4940. Epub 2016 Jul 15.
Muscle-invasive or metastatic bladder cancer (BCa) has a very poor prognosis; however, its mechanisms remain largely unknown. Previous studies have discovered multiple microRNAs (miRs) that are involved in BCa progression and regarded as potential biomarkers or therapeutic targets. In this study, we demonstrated that miR-92b could uniquely promote cell migration and invasion of BCa cells, but had no effect on cell proliferation. Mechanistically, our data provided evidence to verify that miR-92b was able to directly target DAB2IP, a well-known tumor suppressor, and inhibit epithelial‑mesenchymal transition of BCa cells. Moreover, the increased expression levels of miR-92b were negatively correlated with DAB2IP, and predicted poor prognosis of patients with BCa. Overall, this study reveals a new promising biomarker and its mechanisms contributing to BCa invasion or metastasis.
肌肉浸润性或转移性膀胱癌（BCa）的预后非常差；然而，其机制在很大程度上仍不清楚。先前的研究发现了多种参与BCa进展的微小RNA（miR），并将其视为潜在的生物标志物或治疗靶点。在本研究中，我们证明miR-92b能够独特地促进BCa细胞的迁移和侵袭，但对细胞增殖没有影响。从机制上讲，我们的数据提供了证据来证实miR-92b能够直接靶向著名的肿瘤抑制因子DAB2IP，并抑制BCa细胞的上皮-间质转化。此外，miR-92b表达水平的升高与DAB2IP呈负相关，并预测BCa患者的预后较差。总体而言，本研究揭示了一种新的有前景的生物标志物及其促进BCa侵袭或转移的机制。
