Demir Berfu, Bozdag Gurkan, Sengul Ozlem, Kahyaoglu Inci, Mumusoglu Sezcan, Zengin Dila
a Department of Obstetrics and Gynecology , Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital , Ankara , Turkey.
b Department of Obstetrics and Gynecology , Hacettepe University School of Medicine , Ankara , Turkey , and.
Gynecol Endocrinol. 2016 Sep;32(9):741-744. doi: 10.3109/09513590.2016.1161741. Epub 2016 Mar 26.
To determine the impact of salpingectomy on the ovarian reserve. Comparisons are made with the contralateral side in patients with unilateral salpingectomy undergoing intracytoplasmic sperm injection (ICSI) cycles.
Patients under 40 with unilateral salpingectomy and without history of ovarian surgery were selected for the multicentre retrospective study. Women with bilateral salpingectomy and history of endometriosis were excluded from the study. Antral follicle count, controlled ovarian hyperstimulation (COH) parameters and number of collected oocytes were the main outcome measures of the study.
A total of 56 patients were eligible for this study. The mean age of the patients was 31.6 ± 4.7 years. The reasons for the salpingectomy were hydrosalpinx (39.3%, n = 22) and ruptured ectopic pregnancy (60.7%, n = 34). The ongoing pregnancy rate per embryo transfer was 30.6%. There was no statistically significant difference between the operated and non-operated sides in antral follicle count (AFC), follicles ≥ 17 mm and 10-17 mm on day of human chorionic gonadotrophin (hCG), or number of aspirated oocytes. In the subgroup analysis, AFC, number of growing follicles on day of hCG and number of collected oocytes were comparable between the ectopic pregnancy group and hydrosalpinx group.
The study suggests that salpingectomy is not associated with detrimental effects on AFC and ovarian response.
确定输卵管切除术对卵巢储备功能的影响。对接受卵胞浆内单精子注射（ICSI）周期治疗的单侧输卵管切除术患者的患侧与对侧进行比较。
选择年龄小于40岁、单侧输卵管切除且无卵巢手术史的患者进行多中心回顾性研究。双侧输卵管切除及有子宫内膜异位症病史的女性被排除在研究之外。窦卵泡计数、控制性卵巢过度刺激（COH）参数及采集的卵母细胞数量是本研究的主要观察指标。
共有56例患者符合本研究条件。患者的平均年龄为31.6±4.7岁。输卵管切除的原因是输卵管积水（39.3%，n = 22）和异位妊娠破裂（60.7%，n = 34）。每次胚胎移植的持续妊娠率为30.6%。在窦卵泡计数（AFC）、人绒毛膜促性腺激素（hCG）日直径≥17mm及10 - 17mm的卵泡数量或吸出的卵母细胞数量方面，手术侧与非手术侧之间无统计学显著差异。在亚组分析中，异位妊娠组和输卵管积水组在AFC、hCG日生长卵泡数量及采集的卵母细胞数量方面具有可比性。
该研究表明输卵管切除术与对AFC及卵巢反应的不良影响无关。
