饮食和冷适应对大鼠某些组织中脂蛋白脂肪酶活性和环核苷酸水平的影响。

Effects of diets and cold acclimation on lipoprotein lipase activity and cyclic nucleotide levels in some tissues of rats.

作者信息

Bertin R, Goubern M, Portet R

出版信息

Experientia Suppl. 1978;32:185-90. doi: 10.1007/978-3-0348-5559-4_20.

Abstract

In view to study a possible regulation of lipoprotein lipase (LPL) activity by tissue cyclic nucleotide levels (cAMP and cGMP), parallel determinations of the three factors were performed on brown adipose tissue (BAT), epidymal fat (WAT) and heart of rats. Opposite variations of cAMP levels and LPL activity were only observed in WAT following high fat diet administration. The enhancement of LPL activity in BAT and in heart by cold acclimation or feeding an hyperlipidic diet was never associated with a decrease in cAMP content. The variations of cAMP and cGMP levels were not dependent. It is concluded that there is no effect of cyclic nucleotide levels in the enhancement of LPL activity in these tissues.

摘要

为研究组织环核苷酸水平（cAMP和cGMP）对脂蛋白脂肪酶（LPL）活性可能的调节作用，对大鼠的棕色脂肪组织（BAT）、附睾脂肪（WAT）和心脏进行了这三种因素的平行测定。仅在给予高脂饮食后，WAT中观察到cAMP水平和LPL活性的相反变化。冷驯化或给予高脂饮食后BAT和心脏中LPL活性的增强从未与cAMP含量的降低相关。cAMP和cGMP水平的变化相互独立。得出的结论是，环核苷酸水平对这些组织中LPL活性的增强没有影响。