螺旋神经元中单个钙激活钾通道的电压依赖性开放。

Voltage-dependent opening of single calcium-activated potassium channels in Helix neurons.

作者信息

Chagneux H, Ducreux C, Gola M

机构信息

Centre National de la Recherche Scientifique, Laboratoire de Neurobiologie, Marseilles, France.

出版信息

Brain Res. 1989 May 29;488(1-2):336-40. doi: 10.1016/0006-8993(89)90726-9.

DOI:10.1016/0006-8993(89)90726-9

PMID:2743128

Abstract

Single Ca-activated K channels (C channels) were identified in cell-attached patches in Helix neurons. The respective effects of membrane potential and calcium on the opening probability Po were separated by using Ca-free filled patch electrodes. C channels were found to be highly voltage-dependent, with an e-fold increase in Po per 15 mV increase in potential. The location of the Po(V) curve on the voltage axis was dependent on the intracellular Ca concentration. These data indicate that C channels provide the cell with a powerful repolarizing mechanism.

摘要

在海兔神经元的细胞贴附式膜片上鉴定出了单个钙激活钾通道（C通道）。通过使用无钙填充的膜片电极，分离了膜电位和钙对开放概率Po的各自影响。发现C通道高度依赖电压，电位每增加15 mV，Po增加一倍。Po(V)曲线在电压轴上的位置取决于细胞内钙浓度。这些数据表明，C通道为细胞提供了一种强大的复极化机制。