青春期周围给予地西泮可减轻MAM精神分裂症模型大鼠海马小白蛋白的丢失。
Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam.
作者信息
Du Yijuan, Grace Anthony A
机构信息
Departments of Neuroscience (Dr Du, Dr Grace), Psychiatry (Dr Grace), and Psychology (Dr Grace), University of Pittsburgh, Pittsburgh, PA.
出版信息
Int J Neuropsychopharmacol. 2016 Dec 3;19(11). doi: 10.1093/ijnp/pyw065. Print 2016 Nov.
BACKGROUND
Loss of parvalbumin interneurons in the hippocampus is a robust finding in schizophrenia brains. Rats exposed during embryonic day 17 to methylazoxymethanol acetate exhibit characteristics consistent with an animal model of schizophrenia, including decreased parvalbumin interneurons in the ventral hippocampus. We reported previously that peripubertal administration of diazepam prevented the emergence of pathophysiology in adult methylazoxymethanol acetate rats.
METHODS
We used an unbiased stereological method to examine the impact of peripubertal diazepam treatment on parvalbumin interneuron number in the ventral subiculum, dentate gyrus of the hippocampus and the basolateral amygdala.
RESULTS
Methylazoxymethanol acetate rats with peripubertal diazepam showed significantly more parvalbumin interneurons (3355±173 in the ventral subiculum, 1211±76 in the dentate gyrus) than methylazoxymethanol acetate without diazepam (2375±109 and 824±54, respectively). No change was found in the basolateral amygdala.
CONCLUSIONS
Peripubertal diazepam attenuated the decrease of parvalbumin in the ventral hippocampus of methylazoxymethanol acetate rats.
背景
海马体中小清蛋白中间神经元的缺失是精神分裂症患者大脑中的一个显著特征。在胚胎第17天暴露于乙酸甲基氧化偶氮甲醇的大鼠表现出与精神分裂症动物模型一致的特征，包括腹侧海马体中小清蛋白中间神经元减少。我们之前报道过，青春期前给予地西泮可预防成年乙酸甲基氧化偶氮甲醇大鼠病理生理学的出现。
方法
我们使用无偏立体学方法来研究青春期前给予地西泮对腹侧下托、海马齿状回和基底外侧杏仁核中小清蛋白中间神经元数量的影响。
结果
青春期前接受地西泮治疗的乙酸甲基氧化偶氮甲醇大鼠的小清蛋白中间神经元数量（腹侧下托为3355±173，齿状回为1211±76）明显多于未接受地西泮治疗的乙酸甲基氧化偶氮甲醇大鼠（分别为2375±109和824±54）。基底外侧杏仁核未发现变化。
结论
青春期前给予地西泮可减轻乙酸甲基氧化偶氮甲醇大鼠腹侧海马体中小清蛋白的减少。
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