Department of Animal Morphology and Physiology Federal Rural University of Pernambuco Brazil.
Department of Physiotherapy Caruaruense Association of Higher Education Brazil.
Pharmacol Res Perspect. 2016 Apr 7;4(3):e00231. doi: 10.1002/prp2.231. eCollection 2016 Jun.
Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tolerability. Studies have found the following important functions of fluoxetine related to the central nervous system: neuroprotection; anti-inflammatory properties similar to standard drugs for the treatment of inflammatory conditions; antioxidant properties, contributing to its therapeutic action and an important intracellular mechanism underlying the protective pharmacological effects seen in clinical practice in the treatment of different stress-related adverse health conditions; and antiapoptotic properties, with greater neuron survival and a reduction in apoptosis mediators as well as oxidative substances, such as superoxide dismutase and hydrogen peroxide. The aim of this study was to perform a review of the literature on the important role of fluoxetine in anti-inflammatory, cell survival, and neuron trophicity mechanisms (antiapoptotic properties) as well as its role regarding enzymes of the antioxidant defense system.
氟西汀是一种选择性 5-羟色胺再摄取抑制剂，已被广泛用于确定中枢神经系统中 5-羟色胺的神经传递。由于其更安全的特性、更少的副作用和更好的耐受性，这种物质已成为治疗抑郁症的首选药物。研究发现，氟西汀与中枢神经系统相关的以下重要功能：神经保护；与治疗炎症疾病的标准药物具有相似的抗炎特性；抗氧化特性，有助于其治疗作用，也是其在治疗不同与压力相关的不良健康状况时在临床实践中观察到的保护药理学作用的重要细胞内机制；以及抗细胞凋亡特性，可增加神经元存活，减少凋亡介质以及超氧化物歧化酶和过氧化氢等氧化物质。本研究旨在对氟西汀在抗炎、细胞存活和神经元营养机制（抗细胞凋亡特性）中的重要作用以及其在抗氧化防御系统酶方面的作用进行文献回顾。
