综合强化生活方式干预联合二甲双胍缓释片对肥胖青少年的影响
Effects of a Comprehensive, Intensive Lifestyle Intervention Combined with Metformin Extended Release in Obese Adolescents.
作者信息
Clarson Cheril L, Brown Hilary K, De Jesus Stefanie, Jackman Michelle, Mahmud Farid H, Prapavessis Harry, Robinson Tracy, Shoemaker J Kevin, Watson Margaret, Dowd A Justine, Hill David J
机构信息
Children's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9; Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Paediatrics, University of Western Ontario, London, ON, Canada N6A 5A5.
Department of Epidemiology & Biostatistics, University of Western Ontario, London, ON, Canada N6A 5A5.
出版信息
Int Sch Res Notices. 2014 Nov 10;2014:659410. doi: 10.1155/2014/659410. eCollection 2014.
Objective. To assess a comprehensive, intensive lifestyle intervention in combination with metformin extended release (MXR) or placebo on body mass index (BMI) and risk factors for type 2 diabetes and cardiovascular disease in obese adolescents. Study Design. Sixty-nineobese adolescents (mean BMI 32.5) received a comprehensive lifestyle intervention with structured dietary, physical activity, and behavioral components for 24 months. Subjects were randomized to 1 of 4 groups: MXR (33) 2,000 mg daily or placebo, with either moderate or vigorous intensity exercise for the first 3 months. Subsequently the exercise intervention was the same for all 4 groups. Results. Anthropometry measurements did not differ with initial exercise intensity at any time. At 3 months % body fat decreased in all 4 groups (P < 0.006). BMI and % body fat decreased in the MXR groups, but not the placebo groups, at 6 (-0.88, -3.16) and 12 months (-0.56, -2.34) (P < 0.05). Insulin resistance, fasting blood glucose, and leptin improved in all groups at 6 and 12 months. A high subject attrition rate (58%) occurred by 24 months. Conclusion. A comprehensive, intensive lifestyle intervention combined with MXR led to a decline in BMI and % body fat at 1 year independent of initial exercise intensity. This trial is registered with ClinicalTrials.gov NCT00934570 .
目的。评估综合强化生活方式干预联合缓释二甲双胍（MXR）或安慰剂对肥胖青少年体重指数（BMI）以及2型糖尿病和心血管疾病风险因素的影响。研究设计。69名肥胖青少年（平均BMI为32.5）接受了为期24个月的综合生活方式干预，包括结构化饮食、体育活动和行为干预。受试者被随机分为4组中的1组：MXR组（33人），每日服用2000毫克或安慰剂，并在前3个月进行中等强度或高强度运动。随后，所有4组的运动干预相同。结果。人体测量指标在任何时候都不会因初始运动强度而有所不同。3个月时，所有4组的体脂百分比均下降（P < 0.006）。在6个月（-0.88，-3.16）和12个月（-0.56，-2.34）时，MXR组的BMI和体脂百分比下降，而安慰剂组则未下降（P < 0.05）。所有组在6个月和12个月时胰岛素抵抗、空腹血糖和瘦素水平均有所改善。到24个月时，受试者流失率较高（58%）。结论。综合强化生活方式干预联合MXR在1年时可使BMI和体脂百分比下降，且与初始运动强度无关。本试验已在ClinicalTrials.gov注册，注册号为NCT00934570。
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