Zhu Liucun, Zhang Yu-Hang, Su Fangchu, Chen Lei, Huang Tao, Cai Yu-Dong
School of Life Sciences, Shanghai University, Shanghai, People's Republic of China.
Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
PLoS One. 2016 Jul 19;11(7):e0159519. doi: 10.1371/journal.pone.0159519. eCollection 2016.
Biologically, fruits are defined as seed-bearing reproductive structures in angiosperms that develop from the ovary. The fertilization, development and maturation of fruits are crucial for plant reproduction and are precisely regulated by intrinsic genetic regulatory factors. In this study, we used Arabidopsis thaliana as a model organism and attempted to identify novel genes related to fruit-associated biological processes. Specifically, using validated genes, we applied a shortest-path-based method to identify several novel genes in a large network constructed using the protein-protein interactions observed in Arabidopsis thaliana. The described analyses indicate that several of the discovered genes are associated with fruit fertilization, development and maturation in Arabidopsis thaliana.
从生物学角度来看，果实被定义为被子植物中由子房发育而来的带有种子的繁殖结构。果实的受精、发育和成熟对于植物繁殖至关重要，并受到内在遗传调控因子的精确调控。在本研究中，我们以拟南芥作为模式生物，试图鉴定与果实相关生物学过程有关的新基因。具体而言，我们利用经过验证的基因，采用基于最短路径的方法，在一个使用拟南芥中观察到的蛋白质-蛋白质相互作用构建的大型网络中鉴定出几个新基因。所描述的分析表明，发现的几个基因与拟南芥的果实受精、发育和成熟有关。
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