味觉刺激诱发腮腺灌注变化的体素内不相干运动成像测量：一项初步研究。
Intravoxel incoherent motion imaging measurement of perfusion changes in the parotid gland provoked by gustatory stimulation: A pilot study.
作者信息
Becker Anton S, Manoliu Andrei, Wurnig Moritz C, Boss Andreas
机构信息
Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland.
出版信息
J Magn Reson Imaging. 2017 Feb;45(2):570-578. doi: 10.1002/jmri.25393. Epub 2016 Jul 19.
PURPOSE
To demonstrate the feasibility of intravoxel incoherent motion imaging (IVIM) for quantification of perfusion changes in the parotid gland after gustatory stimulation.
MATERIALS AND METHODS
Eight healthy volunteers underwent diffusion-weighted magnetic resonance imaging (MRI) of the neck at 3T with 11 dynamic acquisitions (9 b-values between 0 and 980 s/mm , 2:40 min each). After 5:20 minutes, a lemon-mint-drop was administered orally. Perfusion fraction (F ), pseudodiffusion (D*), tissue diffusion (D ) coefficients, and optimal b-value threshold were measured using a multistep variable b-value threshold fitting approach. Dynamic changes in the coefficients between three exemplary timepoints (baseline, after stimulation, after dissolution) were compared using a Mann-Whitney U-test with Bonferroni correction (P < 0.016 significance level).
RESULTS
Mean values (95% confidence interval [CI]) for IVIM parameters at baseline were F : 0.11 (0.08-0.15), D*: 56.48 mm /s (39.71-98.27), D : 1.01 mm /s (0.84-1.06), b-value threshold: 30 s/mm (21.25-105). After stimulation: F 0.16 (0.15-0.24; P < 0.01), D* 93.83 mm /s (77.98-129.53, P = 0.25), D 0.93 mm /s (0.87-1.08, P = 0.94), b-value threshold 20 s/mm (13.75-26.25 s/mm , P = 0.10), reflecting the increase in tissue perfusion. After dissolution of the drop: F : 0.13 (0.11-0.18, P = 0.38), D*: 101.61 mm /s (90.68-144.55, P = 0.07), D : 0.91 mm /s (0.85-1.05, P = 0.64), b-value threshold: 15 s/mm (11.25-40, P = 0.38).
CONCLUSION
The IVIM method allows for simultaneous quantification of changes in perfusion and diffusion effects after gustatory stimulation of the parotid gland.
LEVEL OF EVIDENCE
2 J. Magn. Reson. Imaging 2017;45:570-578.
目的
探讨体素内不相干运动成像（IVIM）用于量化味觉刺激后腮腺灌注变化的可行性。
材料与方法
8名健康志愿者在3T条件下接受颈部扩散加权磁共振成像（MRI）检查，共进行11次动态采集（9个b值，范围为0至980 s/mm²，每次采集时间为2分40秒）。5分20秒后，口服柠檬薄荷糖。采用多步可变b值阈值拟合方法测量灌注分数（F）、伪扩散系数（D*）、组织扩散系数（D）以及最佳b值阈值。使用Mann-Whitney U检验并进行Bonferroni校正（显著性水平P < 0.016），比较三个典型时间点（基线、刺激后、溶解后）系数的动态变化。
结果
基线时IVIM参数的平均值（95%置信区间[CI]）为：F：0.11（0.08 - 0.15），D*：56.48 mm²/s（39.71 - 98.27），D：1.01 mm²/s（0.84 - 1.06），b值阈值：30 s/mm²（21.25 - 105）。刺激后：F为0.16（0.15 - 0.24；P < 0.01），D为93.83 mm²/s（77.98 - 129.53，P = 0.25），D为0.93 mm²/s（0.87 - 1.08，P = 0.94），b值阈值为20 s/mm²（13.75 - 26.25 s/mm²，P = 0.10），反映了组织灌注增加。糖溶解后：F：0.13（0.11 - 0.18，P = 0.38），D：101.61 mm²/s（90.68 - 144.55，P = 0.07），D：0.91 mm²/s（0.85 - 1.05，P = 0.64），b值阈值：15 s/mm²（11.25 - 40，P = 0.38）。
结论
IVIM方法可同时量化味觉刺激后腮腺灌注和扩散效应的变化。
证据水平
2 J. Magn. Reson. Imaging 2017;45:570 - 578.
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