Husáková M, Láznícek M, Kvĕtina J
Cesk Farm. 1989 Feb;38(1):26-8.
On examining the dependencies between the parameters characterizing the structure and distribution of substances of acid character in the blood of experimental mice in the in vitro conditions it was demonstrated that both plasma and erythrocyte binding are structurally dependent. With increasing lipophilicity, the values of the drug fraction bound to proteins in the separated plasma, the values of the fraction bound to plasma proteins in the samples of whole blood, and the distribution into the erythrocytes in a suspension of erythrocytes are increased. With increasing lipophilicity, the distribution into the erythrocytes in the samples of the whole blood and the fraction in the plasma blood fluid are decreased.
在体外条件下研究表征实验小鼠血液中酸性物质结构和分布的参数之间的相关性时发现，血浆和红细胞结合均与结构有关。随着亲脂性增加，分离血浆中与蛋白质结合的药物分数值、全血样品中与血浆蛋白结合的分数值以及红细胞悬液中进入红细胞的分布增加。随着亲脂性增加，全血样品中进入红细胞的分布以及血浆液中的分数降低。
