Tang Zhankai, Xu Caiming, Zhang Guixin, Chen Hailong
Department of Acute Abdominal Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China (Tang ZK, Xu CM, Zhang GX, Chen HL); Department of Traditional Chinese Medicine, the Affiliated Maternity Hospital of Dalian Medical University, Dalian 116033, Liaoning, China (Xu CM). Corresponding author: Chen Hailong, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2016 Aug;28(8):756-60. doi: 10.3760/cma.j.issn.2095-4352.2016.08.020.
Neuronal guidance factor Netrin-1 has been known to be involved in nervous system development by controlling neuronal migration through both chemoattractive and chemo-repulsive signaling by binding different receptors. Netrin-1 has been shown to play a positively regulatory role during inflammatory process recently. Since the chemorepulsive receptors were found in leukocytes, it is suggest that Netrin-1 played a protective role in tissue through inhibiting leukocyte trafficking and accumulating during inflammatory process in researches. It is demonstrated that Netrin-1 can limit inflammatory response through the involvement of inflammatory cascades, attenuate hypoxia-inducible tissue injury and suppress apoptosis concurrently. It is indicated that Netrin-1 can be a novel target in future through preventing and inhibiting inflammatory diseases in these researches. This review will focus on recent relevant advances and in-depth study to elucidate its mechanism of anti-inflammation.
神经元导向因子Netrin-1已知通过与不同受体结合，利用化学吸引和化学排斥信号控制神经元迁移，从而参与神经系统发育。最近研究表明，Netrin-1在炎症过程中发挥正向调节作用。由于在白细胞中发现了化学排斥受体，因此研究提示Netrin-1在炎症过程中通过抑制白细胞运输和聚集，对组织起到保护作用。研究表明，Netrin-1可通过参与炎症级联反应来限制炎症反应，同时减轻缺氧诱导的组织损伤并抑制细胞凋亡。这些研究表明，Netrin-1有望成为预防和抑制炎症性疾病的新靶点。本综述将聚焦于近期的相关进展及深入研究，以阐明其抗炎机制。
