Swoyer J, Irvine P, Sackett-Lundeen L, Conlin L, Lakatua D J, Haus E
Department of Pathology, St. Paul-Ramsey Medical Center/Ramsey Clinic, MN 55101.
Chronobiol Int. 1989;6(2):131-7. doi: 10.3109/07420528909064623.
Twenty-three clinically healthy, diurnally active elderly subjects, 71 +/- 5 years of age were studied over a 24-hr span (six samples). Complete blood counts and differential counts were done (Ortho ELT-8, Wright stained smears). The circadian rhythm parameters of the hematologic variables in the elderly subjects were compared with reference values obtained from a larger group of clinically healthy young adult and adult subjects studied independently. The data were analyzed by cosinor and the Bingham test. Circadian rhythms in the number of circulating formed elements in the peripheral blood persist in the aged. In comparison with the young adult, the elderly subjects show differences in the timing (phase advance) of the circadian rhythms in circulating neutrophil leukocytes and lymphocytes, a decrease in the circadian amplitude of circulating platelets, a decrease in circadian rhythm adjusted mean (mesor) in the red cell count, and in the neutrophil band forms.
对23名临床健康、日间活动的老年受试者（年龄71±5岁）进行了为期24小时（六个样本）的研究。进行了全血细胞计数和分类计数（使用奥多ELT-8型血细胞分析仪，瑞氏染色涂片）。将老年受试者血液学变量的昼夜节律参数与从另一组独立研究的大量临床健康的年轻成年人和成年人中获得的参考值进行比较。数据采用余弦分析法和宾厄姆检验进行分析。老年人外周血中循环有形成分数量的昼夜节律依然存在。与年轻成年人相比，老年受试者循环中性粒细胞和淋巴细胞昼夜节律的时间（相位提前）存在差异，循环血小板的昼夜振幅降低，红细胞计数和中性粒细胞杆状核的昼夜节律调整均值（中值）降低。
