Enokida Tomohiro, Fujii Satoshi, Kuno Hirofumi, Mukaigawa Takashi, Tahara Makoto, Sakuraba Minoru, Hayashi Ryuichi
Division of Pathology, Exploratory Oncology Research & Clinical Trial Center National Cancer Center, Kashiwa, Chiba, 277-8577, Japan.
Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.
Pathol Int. 2016 Aug;66(8):460-5. doi: 10.1111/pin.12429. Epub 2016 Jul 19.
A 76-year-old Japanese woman had noticed an asymptomatic and palpable mass in her left parotid gland region for 20 years. The tumor had showed rapid growth during the last two months. Therefore, the tumor was clinically suspected of being a malignant tumor and was surgically resected. A histopathological examination revealed that the tumor consisted of two different histopathological neoplastic components accompanied by hyalinized fibrosis at the center of the tumor. The two-neoplastic components were squamous cell carcinoma and salivary duct carcinoma. The tumor was suspected to be a carcinoma ex pleomorphic adenoma after considering the clinical course and the histopathological findings, such as hyalinized fibrosis at the center of the tumor. There was no evidence of recurrence at 30 months after the surgical resection.
一名76岁的日本女性在其左腮腺区域发现一个无症状且可触及的肿块，已持续20年。该肿瘤在过去两个月内迅速生长。因此，临床上怀疑该肿瘤为恶性肿瘤，并进行了手术切除。组织病理学检查显示，肿瘤由两种不同的组织病理学肿瘤成分组成，肿瘤中心伴有玻璃样变性纤维化。这两种肿瘤成分分别为鳞状细胞癌和涎腺导管癌。综合临床病程以及组织病理学表现，如肿瘤中心的玻璃样变性纤维化，怀疑该肿瘤为多形性腺瘤恶变。手术切除30个月后未发现复发迹象。
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